The Contribution of Oxytocin and Vasopressin to Mammalian Social Behavior: Potential Role in Autism Spectrum Disorder
The Contribution of Oxytocin and Vasopressin to Mammalian Social Behavior: Potential Role in Autism Spectrum Disorder
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DOI：
10.1159/000321035
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Wagner, Shlomo
中科院分区：
文献类型：
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作者：
Harony, Hala;Wagner, Shlomo
催产素（OT）和精氨酸-加压素（AVP）是大脑中产生的两种多肽，经脑垂体释放到外周血中，具有多种生理功能。在过去的20年里，人们已经清楚地认识到，这些肽在哺乳动物社会行为的调节中也发挥着核心作用，通过它们在大脑中的活动。一些证据表明，它们与自闭症谱系障碍（ASD）有关，而自闭症谱系障碍被认为与社会认知和行为受损有关。最近对自闭症患者使用OT治疗的临床试验报告了有希望的结果。在这里，我们的目的是描述表明这些肽和ASD之间存在联系的主要数据。在简要介绍ASD生物学中的几个主要主题之后，我们将(a)简要描述大脑中的催产素和血管加压能系统，(b)讨论一些令人信服的案例，表明OT和AVP参与哺乳动物的社会行为，(c)描述支持这些肽在人类社会认知和行为中的作用的数据，以及(d)讨论OT和AVP参与ASD病因学的可能性。以及使用这些肽治疗ASD患者的前景。版权所有：S. Karger AG，巴塞尔
Oxytocin (OT) and arginine-vasopressin (AVP) are 2 peptides that are produced in the brain and released via the pituitary gland to the peripheral blood, where they have diverse physiological functions. In the last 2 decades it has become clear that these peptides also play a central role in the modulation of mammalian social behavior by their actions within the brain. Several lines of evidence suggest their involvement in autism spectrum disorder (ASD), which is known to be associated with impaired social cognition and behavior. Recent clinical trials using OT administration to autistic patients have reported promising results. Here, we aim to describe the main data that suggest a connection between these peptides and ASD. Following a short illustration of several major topics in ASD biology we will (a) briefly describe the oxytocinergic and vasopressinergic systems in the brain, (b) discuss a few compelling cases manifesting the involvement of OT and AVP in mammalian social behavior, (c) describe data supporting the role of these peptides in human social cognition and behavior, and (d) discuss the possibility of the involvement of OT and AVP in ASD etiology, as well as the prospect of using these peptides as a treatment for ASD patients. Copyright (C) 2010 S. Karger AG, Basel