REGULATION OF RENAL WATER-EXCRETION IN NEWBORN FULL-TERM INFANTS
REGULATION OF RENAL WATER-EXCRETION IN NEWBORN FULL-TERM INFANTS
复制标题
DOI：
10.1111/j.1651-2227.1984.tb17764.x
复制
发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
ZETTERSTROM, R
中科院分区：
文献类型：
--
作者：
APERIA, A;HERIN, P;ZETTERSTROM, R
在8小时内，研究了3-4日龄健康足月婴儿对低（45 ml/kg）和高（73 ml/kg）液体摄入量的肾脏反应。20名婴儿接受低液体（LF）摄入，15名婴儿接受高液体（HF）摄入。HF显著增加尿流量，显著降低尿渗透压，但不影响肾小球滤过率（肌酐清除率）。LF组和HF组的血清精氨酸加压素（s-AVP）无差异，且与尿渗透压无关。尿钠排泄量与利尿量呈显著相关。高液体摄入量后，足月婴儿能够通过独立于AVP的机制自适应地排出更大的尿量和更稀的尿，S-AVP似乎与婴儿的水合状态和尿渗透压比成人不同。
The renal response to low (45 ml/kg) and high (73 ml/kg) fluid intake was studied during an 8 h period in healthy 3-4-day-old full-term infants. Twenty infants received low fluid (LF) intake and 15 infants received high fluid (HF) intake. HF significantly increased urine flow and significantly decreased urine osmolality but did not influence glomerular filtration rate measured as the clearance of creatinine. Serum arginine-vasopressin (s-AVP) was not different in the LF and HF groups and did not correlate to urine osmolality. Urinary Na excretion was significantly correlated to the diuresis. Following high fluid intake full-term infants are capable to adaptively excrete larger urine volumes and more dilute urine by mechanisms independent of AVP, S-AVP appears to relate differently to the state of hydration and to urine osmolality in infants than in adults.