Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age.
Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age.
复制标题
DOI：
10.1210/jcem.84.8.5885
复制
发表时间：
1999-08
期刊：
影响因子：
--
通讯作者：
P. Snyder;H. Peachey;P. Hannoush;J. Berlin;Louise Loh;D. Lenrow;J. Holmes;A. Dlewati;Jill Santanna;C. Rosen;B. Strom
中科院分区：
文献类型：
--
作者：
P. Snyder;H. Peachey;P. Hannoush;J. Berlin;Louise Loh;D. Lenrow;J. Holmes;A. Dlewati;Jill Santanna;C. Rosen;B. Strom
随着年龄的增长，男性的血清睾丸素浓度会下降，脂肪的体重百分比会增加，瘦体重的百分比会减少，肌肉力量也会减弱。因为这些变化与性腺功能低下的男性相似，所以我们假设，将65岁以上男性的血清睾酮浓度提高到年轻男性的水平，将减少他们的脂肪质量，增加他们的瘦身质量，并增加他们的肌肉力量。在一项为期36个月的双盲研究中，我们随机选择了108名65岁以上的男性，分别佩戴睾丸素贴片或安慰剂贴片。治疗前和治疗过程中分别采用双能X线骨密度仪和测力仪测定身体成分和肌力。96名男性完成了整个36个月的方案。在治疗的36个月中，服用睾丸酮的男性脂肪质量下降了(-3.0+/-0.5千克)，与安慰剂组男性的下降(-0.7+/-0.5千克)有显著差异(P=0.001)。服用睾丸素的男性瘦体重增加(1.90±-0.3公斤)，与服用安慰剂的男性(0.20+/-0.2公斤)相比有显著差异(P<；0.001)。接受睾丸素治疗的男性脂肪质量的减少主要发生在手臂(与安慰剂组相比为-0.70.1公斤；P<；0.001)和腿部(-1.1%+/-0.2Kg；P<；0.001)，而精瘦质量的增加主要发生在躯干(1.9%+/-0.3Kg；P<；0.001)。然而，在治疗期间，两组在60度和180度角速度下膝关节伸展和屈曲的力量变化没有显著差异。我们的结论是，将65岁以上正常男性的血清睾酮浓度提高到青年男性的中等正常范围，会减少脂肪质量，主要是手臂和腿部的脂肪质量，增加瘦质量，主要是躯干，但不会增加测功机测量的膝关节伸展和屈曲的力量。
As men age, serum testosterone concentrations decrease, the percentage of body mass that is fat increases, the percentage of lean body mass decreases, and muscle strength decreases. Because these changes are similar to those that occur in hypogonadal men, we hypothesized that increasing the serum testosterone concentration of men over 65 yr of age to that in young men would decrease their fat mass, increase their lean mass, and increase their muscle strength. We randomized 108 men over 65 yr of age to wear either a testosterone patch or a placebo patch in a double blind study for 36 months. We measured body composition by dual energy x-ray absorptiometry and muscle strength by dynamometer before and during treatment. Ninety-six men completed the entire 36-month protocol. Fat mass decreased (-3.0+/-0.5 kg) in the testosterone-treated men during the 36 months of treatment, which was significantly different (P = 0.001) from the decrease (-0.7+/-0.5 kg) in the placebo-treated men. Lean mass increased (1.9+/-0.3 kg) in the testosterone-treated men, which was significantly different (P < 0.001) from that (0.2+/-0.2 kg) in the placebo-treated men. The decrease in fat mass in the testosterone-treated men was principally in the arms (-0.7+/-0.1 kg; P < 0.001 compared to the placebo group) and legs (-1.1+/-0.2 kg; P < 0.001), and the increase in lean mass was principally in the trunk (1.9+/-0.3 kg; P < 0.001). The change in strength of knee extension and flexion at 60 degrees and 180 degrees angular velocity during treatment, however, was not significantly different between the two groups. We conclude that increasing the serum testosterone concentrations of normal men over 65 yr of age to the midnormal range for young men decreased fat mass, principally in the arms and legs, and increased lean mass, principally in the trunk, but did not increase the strength of knee extension and flexion, as measured by dynamometer.