Development of congestive heart failure in Japanese patients with atrial fibrillation
Development of congestive heart failure in Japanese patients with atrial fibrillation
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DOI：
10.1253/circj.71.308
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Aizawa, Tadanori
中科院分区：
文献类型：
--
作者：
Fukuda, Taira;Yamashita, Takeshi;Aizawa, Tadanori
背景心房颤动（AF）和充血性心力衰竭（CHF）是经常共存的，但他们的时间关系在日本patients.Methods和结果248 AF患者（63.6 +/- 10.0岁）没有CHF的历史纳入CHF的发展分析在随访期间的49.7 +/- 29.8个月。其中195例无器质性心脏病，22例扩张型或肥厚型心肌病，18例陈旧性心肌梗死，15例瓣膜性心脏病。随访期间，16例患者（6.5%）发生CHF，需要住院治疗（2.0%/患者年）。年龄、性别、左房内径、左室短轴缩短率、高血压和糖尿病与CHF的发生无关，但存在器质性心脏病和左室肥厚与CHF的发生显著相关。Cox-Hazard回归分析显示，结构性心脏病的存在是唯一的独立危险因素（危险比3.50，95%可信区间1.21-10.1）。结论在目前这组日本AF患者中，需要住院治疗的CHF发生率为每年2%。结构性心脏病的存在是该人群中唯一的独立危险因素。
Background Atrial fibrillation (AF) and congestive heart failure (CHF) are frequently coexistent, but their temporal relationship in Japanese patients is unclear.Methods and Results 248 AF patients (63.6 +/- 10.0 years old) without a history of CHF were enrolled for analysis of the development of CHF during the follow-up period of 49.7 +/- 29.8 months. Of them, 195 did not have structural heart disease, 22 had dilated or hypertrophic cardiomyopathy, 18 had an old myocardial infarction, and 15 had valvular heart disease. During the follow-up period, 16 patients (6.5%) developed CHF requiring hospitalization (2.0% per patient-year). Although age, gender, fractional shortening, left atrial diameter, hypertension and diabetes mellitus were not associated with CHF development, existence of structural heart disease and left ventricular,hypertrophy by Cornell voltage criteria on ECG were significantly associated with CHF development. Cox-Hazard regression analysis revealed that the existence of structural heart disease was the only independent risk factor (hazard ratio 3.50, 95%confidence interval 1.21-10.1).Conclusions In the present group of Japanese AF patients, CHF requiring hospitalization occurred at a rate of 2% per year. The existence of structural heart disease was the only independent risk factor in this population.