General Co-catalytic Hydrothiolation of gem-Difluoroalkenes.
General Co-catalytic Hydrothiolation of gem-Difluoroalkenes.
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DOI：
10.1021/acs.joc.2c02343
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Jacob P. Sorrentino;Ryan M Herrick;Mohammed K. Abd El-Gaber;A. Abdelazem;Ankit Kumar;Ryan A. Altman
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文献类型：
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作者：
Jacob P. Sorrentino;Ryan M Herrick;Mohammed K. Abd El-Gaber;A. Abdelazem;Ankit Kumar;Ryan A. Altman
Regioselective functionalization of gem-difluoroalkenes enables convergent late-stage access to fluorinated functional groups, though most functionalization reactions proceed through defluorinative functionalization processes that deliver mono-fluorovinyl products. In contrast, fewer reactions undergo net hydrofunctionalization to generate difluorinated products. Herein, we report a photocatalytic hydrothiolation of gem-difluoroalkenes that enables access to a broad spectrum of α,α-difluoroalkylthioethers. Notably, the reaction successfully couples nonactivated substrates, which expands the scope of accessible molecules relative to previously reported reactions involving organo- or photocatalytic strategies. Further, this reaction successfully couples biologically relevant molecules under aqueous conditions, highlighting potential applications in both late-stage and biorthogonal functionalizations.
