SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN ASSISTED REPRODUCTIVE TECHNOLOGY - DEFINITION OF HIGH-RISK GROUPS
SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN ASSISTED REPRODUCTIVE TECHNOLOGY - DEFINITION OF HIGH-RISK GROUPS
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DOI：
10.1093/oxfordjournals.humrep.a137276
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发表时间：
1991-11-01
影响因子：
6.1
通讯作者：
STONE, SC
中科院分区：
文献类型：
--
作者：
ASCH, RH;LI, HP;STONE, SC
回顾性分析637个周期卵巢刺激和经阴道卵泡抽吸的各种辅助生殖技术，6个周期（0.94%）发生严重卵巢过度刺激综合征（SOH）。在辅助生殖周期中发生SOH的高危患者是在人绒毛膜促性腺激素（HCG）给药当天血清雌二醇水平过高（雌二醇> 6000 pg/ml, 38% SOH）和获得大量卵母细胞（> 30个卵母细胞，23% SOH）的患者。在给药当日雌二醇为> 6000 pg/ml、取卵> 30个的患者中，发生SOH的几率为80%。血清雌二醇水平越高，取卵越多，观察到的怀孕率就越高。高雌二醇水平似乎对怀孕率和结果没有不利影响。此外，我们的结果与在卵巢刺激方案中加入促性腺激素释放激素激动剂、卵泡抽吸和/或黄体支持黄体酮可能降低卵巢过度刺激综合征发生率的建议不一致。
In a retrospective analysis of 637 cycles of ovarian stimulation and transvaginal follicular aspiration for various assisted reproductive technologies, severe ovarian hyperstimulation syndrome (SOH) occurred in six (0.94%) cycles. The patients at a high risk of developing SOH in cycles of assisted reproduction were those who had excessive serum oestradiol levels on the day of human chorionic gonadotrophin (HCG) administration (oestradiol > 6000 pg/ml; 38% SOH) and a high number of oocytes obtained (> 30 oocytes; 23% SOH). In those patients with both oestradiol > 6000 pg/ml on the day of HCG administration and > 30 eggs retrieved, the chance of developing SOH was 80%. The higher the serum oestradiol levels and the more eggs retrieved, the higher the pregnancy rates observed. High oestradiol level did not appear to have a detrimental effect on pregnancy rates and outcome. Furthermore, our results are not consistent with suggestions that the addition of gonadotrophin-releasing hormone agonist to ovarian stimulation protocols, follicular aspiration and/or luteal support with progesterone may reduce the incidence of ovarian hyperstimulation syndrome.