Cyclic estradiol treatment phasically potentiates endogenous cholecystokinin's satiating action in ovariectomized rats
Cyclic estradiol treatment phasically potentiates endogenous cholecystokinin's satiating action in ovariectomized rats
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DOI：
10.1016/s0196-9781(99)00024-8
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发表时间：
1999-01-01
期刊：
影响因子：
3
通讯作者：
Geary, N
中科院分区：
文献类型：
--
作者：
Asarian, L;Geary, N
研究了卵巢周期和外源性雌二醇对完整和去卵巢的龙-埃文斯大鼠胆囊收缩素（CCK）饱足信号系统的影响。腹腔注射1 mg/kg的最有效和选择性的CCK受体拮抗剂德伐匹德，在发情期间增加了试验饲料量，但在发情期间没有增加，证实了下丘脑-垂体-性腺功能对完整大鼠CCK饱腹感的影响。然后在去卵巢大鼠中接受慢性循环雌二醇（每周周二和周三2 μ g苯甲酸雌二醇）或油治疗。与油处理的大鼠相比，在雌二醇治疗前的周二，德伐赛德并没有增加雌二醇治疗大鼠的膳食量，但在雌二醇替代周期的后期，与周二相比，在周期的早期，周五确实选择性地增加了膳食量。这些结果表明，内源性CCK饱腹信号系统的阶段性增强是雌性大鼠发情期进餐量减少的部分机制。(C) 1999 Elsevier Science Inc.；版权所有。
The influence of ovarian cycling and of exogenous estradiol on the cholecystokinin (CCK) satiety-signalling system was investigated in intact and ovariectomized Long-Evans rats, respectively. Intraperitoneal injection of 1 mg/kg devazepide, the most potent and selective CCK, receptor antagonist, increased test meal size during estrus, but not during diestrus, confirming the influence of hypothalamic-pituitary-gonadal function on CCK satiety in intact rats. Devazepide was then tested in ovariectomized rats that received chronic cyclic estradiol (2 mu g estradiol benzoate on Tuesday and Wednesday each week) or oil treatment. Devazepide did not increase meal size in estradiol-treated rats on Tuesday, prior to estradiol treatment, compared to oil-treated rats, but did selectively increase meal size on Friday, late in the estradiol replacement cycle, compared to Tuesday, early in the cycle. These results suggest that a phasic potentiation of the endogenous CCK satiety-signalling system is part of the mechanism for the decrease in meal size in female rats during estrus. (C) 1999 Elsevier Science Inc. All rights reserved.