Peripheral arterial disease in HIV-infected and uninfected women
Peripheral arterial disease in HIV-infected and uninfected women
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DOI：
10.1111/j.1468-1293.2007.00509.x
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发表时间：
2007-11-01
期刊：
影响因子：
3
通讯作者：
Lazar, J.
中科院分区：
文献类型：
--
作者：
Sharma, Anjali;Holman, S.;Lazar, J.
尽管HIV感染与亚临床动脉粥样硬化和心血管事件的风险增加有关，但尚未对HIV感染患者的外周动脉疾病（PAD）进行评估。本研究的目的是确定的患病率，和危险因素，PAD使用踝肱指数（ABI）测量HIV感染者和未感染women.MethodsABI确定为335名参与者在妇女的机构间HIV研究（WIHS）。进行横断面分析，以确定高（>= 1.40）ABI的相关因素。结果低ABI（= 1.40）的患病率为6.9%（n=23）。低ABI的患病率太低，无法进行危险因素分析。在多变量分析中，与高ABI相关的因素是目前吸烟[校正比值比（ORadj）2.53，95%置信区间（CI）0.99-6.43]，体重不足（ORadj11.0，95%CI1.61 -75.63）和超重（ORadj5.40，95%CI1.13 -25.89）。进一步的研究表明，以确定高ABI的临床意义及其与艾滋病毒感染的妇女心血管事件的风险。
ObjectiveAlthough HIV infection has been associated with increased risk of subclinical atherosclerosis and cardiovascular events, peripheral arterial disease (PAD) has not been assessed in HIV-infected patients. The objective of this study was to determine the prevalence of, and risk factors for, PAD using ankle-brachial index (ABI) measurement in HIV-infected and uninfected women.MethodsABI was determined for 335 participants in the Women's Interagency HIV Study (WIHS). A cross-sectional analysis was conducted to determine factors associated with high (>= 1.40) ABI.ResultsThe prevalence of low ABI (= 1.40) was 6.9% (n=23). The prevalence of low ABI was too low to allow risk factor analysis. On multivariate analysis, factors associated with high ABI were current cigarette smoking [adjusted odds ratio (ORadj) 2.53, 95% confidence interval (CI) 0.99-6.43], being underweight (ORadj 11.0, 95% CI 1.61-75.63) and being overweight (ORadj 5.40, 95% CI 1.13-25.89).ConclusionsAlthough the prevalence of ABI = 1.40 was unexpectedly high. Further studies are indicated to determine the clinical significance of high ABI and its relation to the risk of cardiovascular events in HIV-infected women.