Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis
Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis
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DOI：
10.1097/mib.0000000000001023
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发表时间：
2017-03-01
影响因子：
4.9
通讯作者：
Kaplan, Gilaad G.
中科院分区：
文献类型：
--
作者：
Coward, Stephanie;Kuenzig, M. Ellen;Kaplan, Gilaad G.
背景：轻到中度克罗恩病的诱导治疗存在争议。目的：比较不同剂量的美沙拉明、柳氮磺胺吡啶、皮质类固醇和布地奈德对活动期克罗恩病的诱导缓解作用。资料来源：我们从现有的Cochrane综述中确定了随机对照试验，并在Medline、EMBASE和CENTER到2015年11月进行了最新的文献检索。研究选择：我们纳入了22项成年克罗恩病患者的随机对照试验(n=22)，这些试验比较了布地奈德、柳氮磺胺吡啶、美沙拉明或皮质类固醇与安慰剂或彼此之间的诱导缓解(8-17周)。美沙拉明(高于和低于2.4g/d)和布地奈德(高于和低于6 mg/d)被分成低剂量和高剂量。资料提炼：我们的主要结果是缓解，定义为克罗恩病活动指数评分
Background: Induction treatment of mild-to-moderate Crohn's disease is controversial.Purpose: To compare the induction of remission between different doses of mesalamine, sulfasalazine, corticosteroids, and budesonide for active Crohn's disease.Data sources: We identified randomized controlled trials from existing Cochrane reviews and an updated literature search in Medline, EMBASE, and CENTRAL to November 2015.Study selection: We included randomized controlled trials (n = 22) in adult patients with Crohn's disease that compared budesonide, sulfasalazine, mesalamine, or corticosteroids with placebo or each other, for the induction of remission (8-17 wks). Mesalamine (above and below 2.4 g/d) and budesonide (above and below 6 mg/d) were stratified into low and high doses.Data extraction: Our primary outcome was remission, defined as a Crohn's Disease Activity Index score