Progressive multifocal leukoencephalopathy in an HTLV-I carrier
Progressive multifocal leukoencephalopathy in an HTLV-I carrier
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DOI：
10.1016/j.clineuro.2005.09.006
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发表时间：
2006-12-01
影响因子：
1.9
通讯作者：
Kumamoto, Toshihide
中科院分区：
文献类型：
--
作者：
Kimura, Akiko;Ueyama, Hidetsugu;Kumamoto, Toshihide
这份报告描述了一个以前28岁的健康女性，被确定为一个无症状的人类T淋巴细胞病毒I型（HTLV-I）携带者，谁开发进行性多灶性白质脑病（PML）和肺囊虫肺炎。对于PML的诊断确认，立体定向脑活检显示存在JC病毒抗原的多发性脱髓鞘病变。肌内α-干扰素治疗2周带来了相当大的神经功能改善。3年后，患者发生淋巴瘤型成人T细胞白血病，提示HTLV-Ⅰ携带者可能是PML的基础疾病之一。(c)2005 Elsevier B. V.保留所有权利。
This report describes a previously 28-year-old healthy woman, identified as an asymptomatic human T-lymphotropic virus type I (HTLV-I) carrier, who developed both progressive multifocal leukoencephalopathy (PML) and Pneumocystis jiroveci pneumonia. For diagnostic confirmation of PML, stereotactic brain biopsy demonstrated multiple demyelinating lesions with the presence of JC viral antigen. Intramuscular alpha-interferon therapy for 2 weeks brought considerable neurologic improvement. Three years later, the patient developed lymphoma-type of adult T-cell leukemia, suggesting that HTLV-I carrier might be one of the underlying diseases of PML. (c) 2005 Elsevier B.V. All rights reserved.