Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis
Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis
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DOI：
10.1007/s10067-014-2631-1
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Song, Gwan Gyu
中科院分区：
文献类型：
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作者：
Lee, Young Ho;Bae, Sang-Cheol;Song, Gwan Gyu
这项研究的目的是分析已发表的结果，以了解咖啡或茶摄入量与类风湿性关节炎（RA）发生之间的关系。我们通过对已发表的结果进行荟萃分析，调查了咖啡或茶消费与RA发展之间关系的证据。在荟萃分析中考虑了5项研究（3项队列研究和2项病例对照研究），包括134，901例受试者（1，279例RA病例和133，622例非病例）。队列研究的荟萃分析揭示了总咖啡摄入量与RA发病率之间的关联趋势（最高与最低组的相对风险[RR]= 4.148，95%置信区间[CI] = 0.792-21.73，p = 0.092）。病例对照研究的荟萃分析显示，总咖啡摄入量与RA发病率显著相关（RR = 1.201，95%CI = 1.058-1.361，p = 0.005）。结合队列研究和病例对照研究的数据显示，总咖啡摄入量与RA发病率显著相关（RR = 2.426，95%CI = 1.060-5.554，p = 0.036）。按血清阳性分层的荟萃分析表明，咖啡消费与血清阳性RA风险之间存在显著相关性（RR = 1.329，95% CI = 1.162-1.522，p = 3.5 x 10（-5）），但与血清阴性RA风险无关（RR = 1.093，95% CI = 0.884-1.350，p = 0.411）。茶摄入量与类风湿关节炎发病率无相关性（RR = 0.880，95%CI = 0.624-1.239，p = 0.463）.这项对134，901名参与者（大多数参与者是对照组）的荟萃分析表明，高咖啡消费与RA发展风险升高有关。咖啡和RA之间的关联被发现在血清阳性RA，但没有在血清阴性RA。
The aim of this study was to analyze published results for an association between coffee or tea intake and the development of rheumatoid arthritis (RA). We investigated the evidence for a relationship between coffee or tea consumption and the development of RA by performing a meta-analysis of the published results. Five studies (three cohort and two case-control studies) including 134,901 participants (1,279 cases of RA and 133,622 noncases) were considered in the meta-analysis. Meta-analysis of the cohort studies revealed a trend of an association between total coffee intake and RA incidence (relative risk [RR] of the highest versus the lowest group = 4.148, 95 % confidence interval [CI] = 0.792-21.73, p = 0.092). Meta-analysis of case-control studies showed a significant association between total coffee intake and RA incidence (RR = 1.201, 95 % CI = 1.058-1.361, p = 0.005). Combining the data of the cohort and case-control studies showed a significant association between total coffee intake and RA incidence (RR = 2.426, 95 % CI = 1.060-5.554, p = 0.036). Meta-analysis stratified by seropositivity indicated a significant association between coffee consumption and seropositive RA risk (RR = 1.329, 95 % CI = 1.162-1.522, p = 3.5 x 10(-5)), but not seronegative RA risk (RR = 1.093, 95 % CI = 0.884-1.350, p = 0.411). No association was found between tea intake and RA incidence (RR = 0.880, 95 % CI = 0.624-1.239, p = 0.463). This meta-analysis of 134,901 participants (most of the participants were controls) suggests that high coffee consumption is associated with an elevated risk of RA development. The association between coffee and RA was found in seropositive RA, but not in seronegative RA.