Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses
Soluble Interleukin-6 Receptor-Mediated Innate Immune Response to DNA and RNA Viruses
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可溶性白细胞介素 6 受体介导的 DNA 和 RNA 病毒先天免疫反应
DOI：
10.1128/jvi.01248-13
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发表时间：
2013-08
影响因子：
5.4
通讯作者：
Zhu, Ying
中科院分区：
文献类型：
--
作者：
Wang, Hui;Zhu, Chengliang;Liu, Shi;Zhu, Ying
ABSTRACT The interleukin-6 (IL-6) receptor, which exists as membrane-bound and soluble forms, plays critical roles in the immune response. The soluble IL-6 receptor (sIL6R) has been identified as a potential therapeutic target for preventing coronary heart disease. However, little is known about the role of this receptor during viral infection. In this study, we show that sIL6R, but not IL-6, is induced by viral infection via the cyclooxygenase-2 pathway. Interestingly, sIL6R, but not IL-6, exhibited extensive antiviral activity against DNA and RNA viruses, including hepatitis B virus, influenza virus, human enterovirus 71, and vesicular stomatitis virus. No synergistic effects on antiviral action were observed by combining sIL6R and IL-6. Furthermore, sIL6R mediated antiviral action via the p28 pathway and induced alpha interferon (IFN-α) by promoting the nuclear translocation of IFN regulatory factor 3 (IRF3) and NF-κB, which led to the activation of downstream IFN effectors, including 2′,5′-oligoadenylate synthetase (OAS), double-stranded RNA-dependent protein kinase (PKR), and myxovirus resistance protein (Mx). Thus, our results demonstrate that sIL6R, but not IL-6, plays an important role in the host antiviral response.
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影响因子：
3.7
作者：
Prescott J;Hall P;Acuna-Retamar M;Ye C;Wathelet MG;Ebihara H;Feldmann H;Hjelle B
通讯作者：
Hjelle B
影响因子：
64.5
作者：
Hatziapostolou M;Polytarchou C;Aggelidou E;Drakaki A;Poultsides GA;Jaeger SA;Ogata H;Karin M;Struhl K;Hadzopoulou-Cladaras M;Iliopoulos D
通讯作者：
Iliopoulos D
影响因子：
100.3
作者：
Qiutang Li;I. Verma
通讯作者：
Qiutang Li;I. Verma
影响因子：
30.3
作者：
Zhao L;Jha BK;Wu A;Elliott R;Ziebuhr J;Gorbalenya AE;Silverman RH;Weiss SR
通讯作者：
Weiss SR
DOI：
10.1084/jem.20111504
发表时间：
2012-10-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Karnowski A;Chevrier S;Belz GT;Mount A;Emslie D;D'Costa K;Tarlinton DM;Kallies A;Corcoran LM
通讯作者：
Corcoran LM