alpha-Melanocyte-stimulating hormone-induced eruptive nevi.
alpha-Melanocyte-stimulating hormone-induced eruptive nevi.
复制标题
α-黑素细胞刺激激素诱发的发疹性痣。
作者：
A. Cardones;J. Grichnik
背景
靶向阿黑皮质素原受体的合成肽正在被研究作为一种新颖且安全的晒黑方法。据推测，合成的α-黑素细胞刺激激素（α-MSH）肽由于其黑色素生成活性，可能对黑色素瘤的发展具有保护作用。然而，它们的最终生物学效应，特别是对于患有发育不良痣或既往黑色素瘤的患者，尚未确定。
观察结果
一名 40 岁白人男子，有黑色素瘤和多发性发育不良痣病史，自行注射了合成 α-MSH。他开发了一系列新的色素痣，其中许多具有非典型的临床和组织病理学特征。先前存在的痣变得更黑并获得生长特征。停止使用 α-MSH 后，痣逐渐变浅并失去生长特征。
结论
合成的 α-MSH 肽可以促进易感患者体内肿瘤性黑素细胞的增殖。这可能会增加患黑色素瘤的风险。
BACKGROUND
Synthetic peptides that target proopiomelanocortin receptors are being investigated as a novel and safe way to tan. It has been postulated that synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) peptides may have protective effects against the development of melanoma because of their melanogenic activity. Their ultimate biological effect, however, especially in patients with dysplastic nevi or previous melanoma, has yet to be determined.
OBSERVATIONS
A 40-year-old white man with a history of melanoma and multiple dysplastic nevi self-administered synthetic alpha-MSH. He developed crops of new pigmented nevi, many of which had atypical clinical and histopathologic features. The preexisting nevi became darker and acquired growth features. After alpha-MSH use was discontinued, the nevi progressively lightened and lost their growth features.
CONCLUSIONS
Synthetic alpha-MSH peptides can drive proliferation of neoplastic melanocytic cells in predisposed patients. This could present an increased risk for melanoma development.