Familial aggregation of VO2max response to exercise training:: results from the HERITAGE Family Study
Familial aggregation of VO2max response to exercise training:: results from the HERITAGE Family Study
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DOI：
10.1152/jappl.1999.87.3.1003
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发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Rao, DC
中科院分区：
文献类型：
--
作者：
Bouchard, C;An, P;Rao, DC
本研究的目的是测试的假设，最大的O-2摄取（（V）超过点O-2 max）的反应，以一个标准化的训练计划的个体差异的特点是家庭聚集。对来自98个两代同堂家庭的481名成年白种人进行为期20周的运动训练，并在训练前和训练后两次在自行车测力计上测试（V）超过点（2 max）。（V）超过点O-2 max的平均增加达到了400 ml/min，但反应性存在相当大的异质性，一些个体几乎没有或没有增加，而另一些个体增加了>1.0 l/min。ANOVA显示，在（V）超过点O-2 max的反应方差中，家族间的方差是家族内的2.5倍。通过使用模型拟合程序，最简约的模型得出（V）过点O-2 max响应的最大遗传力估计值为47%，其中一个模型中的母体传播率为28%，并根据年龄和性别进行了调整。我们的结论是，（V）超过点O-2 max的可训练性是高度家族性的，包括一个显着的遗传成分。
The aim of this study was to test the hypothesis that individual differences in the response of maximal O-2 uptake ((V)over dot O-2max) to a standardized training program are characterized by familial aggregation. A total of 481 sedentary adult Caucasians from 98 two-generation families was exercise trained for 20 wk and was tested for (V)over dot (2max) on a cycle ergometer twice before and twice after the training program. The mean increase in (V)over dot O-2max reached similar to 400 ml/min, but there was considerable heterogeneity in responsiveness, with some individuals experiencing little or no gain, whereas others gained >1.0 l/min. An ANOVA revealed that there was 2.5 times more variance between families than within families in the (V)over dot O-2max response variance. With the use of a model-fitting procedure, the most parsimonious models yielded a maximal heritability estimate of 47% for the (V)over dot O-2max response, which was adjusted for age and sex with a maternal transmission of 28% in one of the models. We conclude that the trainability of (V)over dot O-2max is highly familial and includes a significant genetic component.