Complete Genome Sequence of an Avian Leukosis Virus Isolate Associated with Hemangioma and Myeloid Leukosis in Egg-Type and Meat-Type Chickens
Complete Genome Sequence of an Avian Leukosis Virus Isolate Associated with Hemangioma and Myeloid Leukosis in Egg-Type and Meat-Type Chickens
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与蛋型和肉型鸡血管瘤和骨髓性白血病相关的禽白血病病毒分离株的完整基因组序列
DOI：
10.1128/jvi.01894-12
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发表时间：
2012-10-01
影响因子：
5.4
通讯作者：
Bi, Yingzuo
中科院分区：
文献类型：
--
作者：
Ji, Jun;Li, Hongxin;Bi, Yingzuo
J亚群禽白血病病毒（ALV-J）首次从发生骨髓性白血病（ML）的肉鸡中分离到。近年来，在我国暴露于ALV-J的商业蛋鸡群中，有大量的病例报告发生血管瘤（HE）或HE和ML，而不是单独的ML。本文报道了一株在中国引起蛋用鸡和肉用鸡HE和ML的ALV-J分离株的全基因组序列。这些发现将为ALV-J的基因组、宿主范围和致病性的分子特征提供更多的见解。
ABSTRACT Subgroup J avian leukosis virus (ALV-J) was first isolated from meat-type chickens that developed myeloid leukosis (ML). In recent years, field cases of hemangioma (HE) or HE and ML, rather than ML alone, have been reported in commercial layer flocks exposed to ALV-J with a high incidence in China. Here we report the complete genomic sequence of an ALV-J isolate that caused both HE and ML in egg-type and meat-type chickens in China. These findings will provide additional insights into the molecular characteristics in genomes, host range, and pathogenicity of ALV-J.