THREE CASES OF CHLOROQUINE RETINOPATHY A FOLLOW‐UP INVESTIGATION
THREE CASES OF CHLOROQUINE RETINOPATHY A FOLLOW‐UP INVESTIGATION
复制标题
氯喹视网膜病变三例随访调查
DOI：
10.1111/j.1755-3768.1966.tb08043.x
复制
发表时间：
1966
影响因子：
3.4
通讯作者：
O. Carlberg
中科院分区：
文献类型：
--
作者：
O. Carlberg
重要的是扩大我们对通常患有红斑狼疮或类风湿关节炎的患者治疗期间可能出现的视网膜并发症的晚期病程的认识；这只能通过后续检查来完成。这一领域的经典是Hobbs等人在1959年和1961年出版的出版物（12,13）和Bernstein的重要评论(4)。氯喹视网膜病变最重要的症状和体征是主观视力障碍、视力下降、视野缺损、眼底血管收缩和色素改变。后者通常位于中心，并且具有引起“牛眼”和“甜甜圈”描述的外观，深色中心被较白的区域包围，而较白的区域又被较深的色素带包围。彩色视觉的干扰已经被描述（20,1,18），视网膜电图（ERG）和眼电图（EOG）的变化（2,3,9,10,15,19,20）。视网膜病变有时与角膜沉积有关（10,11,12,16,21,24,26）。霍布斯（12,13,16）和其他人报道了某些特别严重的病例中受损的光感知。有关发病率的数据各不相同，霍布斯给出的数字是2.9%（13）。
I t is important to widen our knowledge of the late course of the retinal complications that may develop during the treatment of patients, usually suffering from lupus erythematosus or rheumatoid arthritis, with synthetic antimalarials; this can only be accomplished by means of follow-up examinations. Classics in this field are the publications of Hobbs et al. which appeared in 1959 and 1961 (12,13) and the important review of Bernstein (4) . The most important symptoms and signs in chloroquine retinopathy are subjective disturbances of vision, diminished visual acuity, defects in the visual fields, and vascular constriction and pigmentary changes in the fundi. The latter are commonly central, and have an appearance that has given rise to the descriptions “bull’s eye” and “doughnut”, a dark centre is surrounded by a paler zone which in turn is encircled by a darker, pigmented band. Disturbances of colour vision have been described (20, 1, 18), as have electroretinographic (ERG) and electro-oculographic (EOG) changes (2, 3, 9, 10, 15, 19, 20). Retinopathy has occasionally been associated with corneal deposits (10, 11, 12, 16, 21, 24, 26). Impaired light perception has been reported in certain particularly severe cases by Hobbs ( 12, 13,16) and others. Data concerning incidence vary, Hobbs gives a figure of 2.9 % (13).