Glycolipids from sponges.: 6.: Plakoside A and B, two unique prenylated glycosphingolipids with immunosuppressive activity from the marine sponge Plakortis simplex
Glycolipids from sponges.: 6.: Plakoside A and B, two unique prenylated glycosphingolipids with immunosuppressive activity from the marine sponge Plakortis simplex
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DOI：
10.1021/ja9727225
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发表时间：
1997-12-24
影响因子：
15
通讯作者：
Ianaro, A
中科院分区：
文献类型：
--
作者：
Costantino, V;Fattorusso, E;Ianaro, A
从海绵Plakortis simplex中分离到两种独特的鞘脂糖苷A （la）和B(29)，并通过光谱学和化学方法对其结构进行了鉴定。白皂苷对活化的T细胞有很强的免疫抑制作用，被证明是一种有用的自然模型，可以更好地理解鞘糖脂免疫调节活性的结构要求。
Plakoside A (la) and B (29), two unique glycosphingolipids belonging to a new class of prenylated glycolipid, have been isolated from the marine sponge Plakortis simplex, and their structures have been determined by spectroscopic and chemical means. Plakosides are strongly immunosuppressive on activated T cells and proved to be useful natural models for an improved comprehension of the structural requirements for immunomodulating activity of glycosphingolipids.