Structure and formation of the cytomegalovirus virion.

Structure and formation of the cytomegalovirus virion.
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DOI:
10.1007/978-3-540-77349-8_11
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发表时间:
2008
影响因子:
--
通讯作者:
Wade Gibson
Wade Gibson
中科院分区:
医学3区
文献类型:
--
作者:
Wade Gibson

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疱疹病毒核复制双链DNA基因组的运输和保护是由病毒粒子及其亚结构完成的。对这些颗粒的组成、组织和形成的研究已经为病毒组装的分子机制提供了洞察力,为抗病毒策略提供了指导,并提供了关于病毒复制所需、类似或拮抗病毒复制的细胞过程的信息。本章更新了早期关于人类巨细胞病毒(HCMV)病毒粒子的结构和形成的综述(Gibson 1996,2006;Eickmann等人。2006年),并补充了本卷中提出的关于疱疹病毒结构和复制的其他几个评论(参见E.Murphy和T.Shenk、Z.Ruzcitical和U.Koszinowski、R.Kalejta和GS Pari的章节)以及其他地方(Rixon 1993;Steven和Spear 1997;Brown等人)。2002年;Varnum等人。2004年;刘和周2007年)。
Transport and protection of the nuclear-replicating double-stranded DNA genome of herpesviruses is accomplished by the virion and its substructures. Studies of the composition, organization, and formation of these particles have provided insight into the molecular mechanisms of virus assembly, leads for antiviral strategies, and information about cellular processes that are required for, resemble, or antagonize virus replication. This chapter updates earlier reviews on the structure and formation human cytomegalovirus (HCMV) virions (Gibson 1996, 2006; Eickmann et al. 2006), and complements several other reviews on herpesvirus structure and replication presented in this volume (see the chapters by E. Murphy and T. Shenk, Z. Ruzsics and U. Koszinowski, R. Kalejta, and GS Pari) and elsewhere (Rixon 1993; Steven and Spear 1997; Brown et al. 2002; Varnum et al. 2004; Liu and Zhou 2007).