A review of ERGIC-53: its structure, functions, regulation and relations with diseases.
A review of ERGIC-53: its structure, functions, regulation and relations with diseases.
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DOI：
10.14670/hh-24.1193
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发表时间：
2009-09
影响因子：
2
通讯作者：
Yong Zhang;Yuan Zhou;Chun-zheng Yang;D. Xiong
中科院分区：
文献类型：
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作者：
Yong Zhang;Yuan Zhou;Chun-zheng Yang;D. Xiong
ERGIC-53是一种I型跨膜蛋白。ERGIC-53包括N端信号序列、钙依赖性和pH敏感性的糖识别结构域、茎区、跨膜结构域和短胞质结构域; ERGIC-53主要作为有限数量糖蛋白的受体，将其从ER转运到ERGIC和高尔基体，同时还具有次要的糖蛋白质量控制功能。最近的研究表明，UPR，热休克和VIPL可能调节ERGIC-53的表达。F5 F8 D，以及一些内质网储存疾病与ERGIC-53有关。
ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.