An embedded subnetwork of highly active neurons in the neocortex.
An embedded subnetwork of highly active neurons in the neocortex.
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DOI：
10.1016/j.neuron.2010.11.029
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发表时间：
2010-12-22
期刊：
影响因子：
16.2
通讯作者：
Barth, Alison L.
中科院分区：
文献类型：
--
作者：
Yassin, Lina;Benedetti, Brett L.;Jouhanneau, Jean-Sebastien;Wen, Jing A.;Poulet, James F. A.;Barth, Alison L.
评估新皮层单个神经元放电活动的无偏方法显示，很大一部分细胞以极低的速率（<0.1 Hz）自发和诱发活动放电。因此，新皮质网络的放电似乎是由一小群高度活跃的神经元控制的。在这里，我们使用fosGFP转基因小鼠来检查具有近期活性升高历史的细胞的特性。无论在体内还是体外，表达fosGFP的2/3层锥体细胞的放电率都高于fosGFP−神经元。活性升高可归因于对fosGFP+神经元的兴奋性驱动增加和抑制性驱动减少。配对细胞记录表明，fosGFP+神经元更有可能相互连接。这些发现表明，新皮层中存在高度活跃、相互连接的神经元群，并表明这些细胞可能在感觉信息编码中发挥作用。
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP− neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP+ neurons. Paired-cell recordings indicated that fosGFP+ neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
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