Neuroanatomical markers of genetic liability to psychosis and first episode psychosis: A voxelwise meta-analytical comparison
Neuroanatomical markers of genetic liability to psychosis and first episode psychosis: A voxelwise meta-analytical comparison
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DOI：
10.3109/15622975.2011.630408
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发表时间：
2014-04-01
影响因子：
3.1
通讯作者：
Borgwardt, S.
中科院分区：
文献类型：
--
作者：
Fusar-Poli, P.;Smieskova, R.;Borgwardt, S.
目标.在荟萃分析水平上探讨精神病遗传易感性和精神病首次发作的神经解剖学标志物。方法.在精神病遗传高危（HR）或首次发作精神病（FEP）的抗精神病药物初治受试者中进行的15项基于体素的形态测定（VBM）研究被纳入符号差分映射（SDM）荟萃分析。用漏斗图和Egger截距评估发表偏倚。用Q统计量和I2指数评价异质性。结果该数据库包括458 HR和206抗精神病药初治FEP受试者，与对照组相匹配。与对照组相比，在HR组的左侧海马旁回和双侧前扣带回中观察到灰质（GM）减少，在FEP组的右侧上级颞回、左侧小脑和左侧小脑中观察到灰质（GM）减少。与HR组相比，FEP组在左前扣带回、右楔前叶、左小脑和右上级颞回中观察到GM进一步降低。局限性。纳入研究的横断面性质阻止了对后来发生或未发生精神病发作的高风险受试者进行比较。其他注意事项是基于个体成像研究的方法学异质性。结论.前扣带回中GM的减少是精神病遗传易感性的标志，而上级颞回和小脑的减少可以解释为疾病首次发作的标志。
Objectives. To address at a meta-analytical level the neuroanatomical markers of genetic liability to psychosis and a of first episode of psychosis. Methods. Fifteen voxel-based morphometry (VBM) studies of antipsychotic-naive subjects at genetic high-risk (HR) for psychosis or with a first-episode psychosis (FEP) were included in a Signed Differential Mapping (SDM) meta-analysis. Publication bias was assessed with funnel plots and Egger's intercept. Heterogeneity was assessed with Q statistics and I 2 index. Results. The database comprised 458 HR and 206 antipsychotic-naive FEP subjects, matched with controls. Gray matter (GM) reductions as compared to controls, were observed in the left parahippocampal gyrus and in the bilateral anterior cingulate gyrus in the HR group, and in the right superior temporal gyrus, in the left insula and in the left cerebellum in the FEP group. Further GM decreases were observed in the FEP group as compared to the HR group in the left anterior cingulate, in the right precuneus, in the left cerebellum and in the right superior temporal gyrus. Limitations. The cross-sectional nature of the included studies prevented the comparison of high risk subjects who later did or did not develop a psychotic episode. Other caveats are based on the methodological heterogeneity across individual imaging studies. Conclusions. GM reductions in the anterior cingulate are markers of genetic liability to psychosis while reductions in the superior temporal gyrus and cerebellum can be interpreted as markers of a first onset of the illness.