Challenges to biobanking in LMICs during COVID-19: time to reconceptualise research ethics guidance for pandemics and public health emergencies?
Challenges to biobanking in LMICs during COVID-19: time to reconceptualise research ethics guidance for pandemics and public health emergencies?
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2019冠状病毒病期间中低收入国家生物库面临的挑战：是时候重新考虑流行病和突发公共卫生事件的研究伦理指南了？
DOI：
10.1136/medethics-2020-106858
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发表时间：
2022-07
影响因子：
4.1
通讯作者：
Moodley K
中科院分区：
文献类型：
--
作者：
Singh S;Cadigan RJ;Moodley K
生物样本库能够促进有价值的健康研究，进而可能带来显著的社会效益。然而，为研究目的收集、储存和共享人类样本及数据带来了众多伦理挑战。当生物样本库工作旨在促进对突发公共卫生事件的研究，并包括在中低收入国家（LMICs）和高收入国家（HICs）之间共享样本和数据时，这些挑战会加剧。在本文中，我们探讨了新冠病毒生物样本库面临的伦理挑战，并列举了中低收入国家过去两次传染病疫情的例子，在这些疫情中生物样本库活动加剧了全球不平等。我们关注在突发公共卫生事件期间促进公共利益的伦理必要性如何与保护生物样本库参与者的利益相冲突。我们讨论了在突发公共卫生事件期间，在有适当指导以防止生物剽窃和对弱势群体的剥削的前提下，在免除知情同意的情况下进行生物样本库研究在伦理上是可允许的。我们还强调了中低收入国家和高收入国家之间开展生物样本库合作以促进能力建设和利益共享的必要性。最后，我们提供了指导意见，以促进在新冠疫情或其他未来突发公共卫生事件期间对生物样本库及生物样本库研究进行伦理监督。
Biobanking can promote valuable health research that may lead to significant societal benefits. However, collecting, storing and sharing human samples and data for research purposes present numerous ethical challenges. These challenges are exacerbated when the biobanking efforts aim to facilitate research on public health emergencies and include the sharing of samples and data between low/middle-income countries (LMICs) and high-income countries (HICs). In this article, we explore ethical challenges for COVID-19 biobanking, offering examples from two past infectious disease outbreaks in LMICs where biobanking activities contributed to the perpetuation of global inequities. We focus on how the ethical imperative to promote the common good during public health emergencies can conflict with protecting the interests of biobank participants. We discuss how conducting biobank research under a waiver of informed consent during public health emergencies is ethically permissible, provided guidance is in place to prevent biopiracy and exploitation of vulnerable communities. We also highlight the need for biobank collaborations between LMICs and HICs to promote capacity building and benefit sharing. Finally, we offer guidance to promote the ethical oversight of biobanks and biobank research during the COVID-19 pandemic or other future public health emergencies.
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影响因子：
1.6
作者：
Allocca, Clare M.;Bledsoe, Marianna J.;Snapes, Emma
通讯作者：
Snapes, Emma
低收入和中等收入国家 COVID-19 大流行期间焦虑症状的频率和相关性：一项跨国研究。
影响因子：
4.8
作者：
Cénat JM;Dalexis RD;Guerrier M;Noorishad PG;Derivois D;Bukaka J;Birangui JP;Adansikou K;Clorméus LA;Kokou-Kpolou CK;Ndengeyingoma A;Sezibera V;Auguste RE;Rousseau C
通讯作者：
Rousseau C
影响因子：
4
作者：
Canario Guzman, Julio Arturo;Espinal, Roberto;Rafael Mendoza, Eddys
通讯作者：
Rafael Mendoza, Eddys
影响因子：
3.3
作者：
Gostin, Lawrence O.;Friedman, Eric A.;Wetter, Sarah A.
通讯作者：
Wetter, Sarah A.
影响因子：
1.6
作者：
Gao, Frank, I;Tao, Liang;Shu, Zhiquan
通讯作者：
Shu, Zhiquan