Brown adipose tissue - More than an effector of thermogenesis?
Brown adipose tissue - More than an effector of thermogenesis?
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DOI：
10.1111/j.1749-6632.1998.tb08325.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Nedergaard, J
中科院分区：
文献类型：
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作者：
Cannon, B;Houstek, J;Nedergaard, J
棕色脂肪组织(BAT)通过氧化脂肪酸产生热量。这发生在组织受到去甲肾上腺素刺激的时候；BAT产生热量的能力的分子背景是组织特有的线粒体蛋白UCP1，在BAT关于发烧的经典观点中，BAT是一个效应器官，产生热量，特别是在发烧的开始阶段。有很好的证据表明，BAT的产热是通过内毒素(LPS)、白介素1β(IL-1β)、白介素6(IL-6)、前列腺素E(Prostaglandin E)级联刺激的。在不断刺激活动的生理条件下，BAT有望被招募，但在发烧时，这只在甲状腺激素热中明显。然而，蝙蝠可能不仅仅是一个效应器。有迹象表明，BAT的数量和发烧的强度之间存在相关性，棕色脂肪细胞确实可以产生IL-1α和IL-6。此外，棕色脂肪细胞对内毒素直接敏感；这种内毒素敏感性在IL-1β缺陷小鼠的棕色脂肪细胞中增强。因此，BAT也可能在体温调节中起着控制作用。去除发热和蝙蝠产热中心蛋白的转基因小鼠的存在，为鉴定和阐明棕色脂肪组织作为参与控制发热的内分泌器官的这一假定的新角色打开了可能性。
Brown adipose tissue (BAT) produces heat by oxidation of fatty acids. This takes place when the tissue is stimulated by norepinephrine; the molecular background for the ability of BAT to produce heat is the tissue-specific mitochondrial protein UCP1, In the classic view of BAT with respect to fever, BAT is an effector organ, producing heat especially during the onset phase of the fever. There is good evidence that BAT thermogenesis is stimulated via a lipopolysaccharide (LPS), interleukin (IL)-1 beta, IL-6, prostaglandin E cascade. Under physiologic conditions of constantly stimulated activity, BAT is expected to be recruited, but in fevers this is only evident in thyroxine fever. However, BAT may be more than merely an effector. There are indications of a correlation between the amount of BAT and the intensity of fevers, and brown adipocytes can indeed produce IL-1 alpha and IL-6. Furthermore, brown adipocytes are directly sensitive to LPS; this LPS sensitivity is augmented in brown adipocytes from IL-1 beta-deficient mice. Thus, BAT may also have a controlling role in thermoregulation. The existence of transgenic mice with ablations of proteins central in fever and in BAT thermogenesis opens up possibilities for identification and elucidation of this putative new role for brown adipose tissue as an endocrine organ involved in the control of fever.