Long-term functional outcome of brachytherapy for carcinoma of the mobile tongue: focus on the atrophic change of irradiated tongue.
Long-term functional outcome of brachytherapy for carcinoma of the mobile tongue: focus on the atrophic change of irradiated tongue.
复制标题
近距离放射治疗活动舌癌的长期功能结局：关注受照射舌的萎缩变化。
DOI：
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复制
发表时间：
2006
影响因子：
2.4
通讯作者：
H. Honda
中科院分区：
文献类型：
--
作者：
Y. Urashima;Katsumasa Nakamura;Y. Shioyama;Tomonari Sasaki;S. Ohga;T. Toba;N. Kunitake;Tooru Chikui;T. Kawazu;Tomomi Yamada;H. Terashima;H. Honda
目标
评估移动舌癌患者间质放射治疗后的舌萎缩和长期功能结果。
方法
在2002年7月至2004年4月期间接受评估的493名可动舌鳞状细胞癌接受低剂量近距离放射治疗的患者中，有57名患者的舌头未经过外科手术修改且没有原发性复发。从治疗到评估的中位时间为 96 个月（范围：9-214 个月）。几乎所有患者均属于早期舌癌（T1/T2/T3/T4=30:24:3:0），且均接受过单平面种植体间质放疗。为了评估舌头的畸形，我们使用了分级系统，将舌头的萎缩性变化分为四类（G0-G3）。
结果
39 名患者（70%）在受照射侧表现出轻度舌偏侧萎缩（G1 或 G2）。然而，没有患者出现严重萎缩，即舌头无法伸出门牙（G3）。近距离放射治疗后的时间长度>72个月，近距离放射治疗患者的年龄具有相同的统计学意义（P=0.0366）。至于功能结果，几乎所有患者都保留了言语的可理解性和正常饮食。
结论
近距离放射治疗后的很长一段时间内，受照射的舌头会出现萎缩性变化。然而，大多数患者可以维持日常生活活动而不受严重限制。
OBJECTIVE
To assess tongue atrophy and long-term functional outcome of mobile tongue cancer patients after interstitial radiotherapy.
METHODS
Of 493 patients whose squamous cell carcinoma of the mobile tongue had been treated with low dose rate brachytherapy, there were 57 patients evaluated between July 2002 and April 2004 whose tongue had not been modified by surgical procedures and who had no primary recurrence. The median time from treatment to evaluation was 96 months (range: 9-214 months). Almost all of the patients belonged to the early stage tongue cancer (T1/T2/T3/T4=30:24:3:0), and all had received interstitial radiotherapy with a single-plane implant. To evaluate the deformity of the tongue, we used a grading system that classified the atrophic changes of the tongue into four categories (G0-G3).
RESULTS
Thirty-nine patients (70%) showed mild tongue hemiatrophy (G1 or G2) in the irradiated side. However, no patients showed severe atrophy where the tongue cannot be made to protrude beyond the incisors (G3). The length of time after brachytherapy was >72 months and the age of the patients at brachytherapy had the same statistical significance (P=0.0366). As for functional outcome, understandability of speech and a normal diet were preserved for almost all patients.
CONCLUSION
The progression of atrophic change in the irradiated tongue occurred over a long term after brachytherapy. However, most patients could maintain their activities of daily life without severe restriction.
影响因子：
5.7
作者：
BENTZEN, SM;THAMES, HD;OVERGAARD, M
通讯作者：
OVERGAARD, M
DOI：
10.1016/0360-3016(91)90058-c
发表时间：
1991
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Powers,BE;Gillette,EL;Gillette,SL;LeCouteur,RA;Withrow,SJ
通讯作者：
Withrow,SJ