Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women
Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women
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DOI：
10.1249/mss.0b013e3182059eda
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Kurzer, Mindy S.
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文献类型：
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作者：
Arikawa, Andrea Y.;Thomas, William;Kurzer, Mindy S.
有川，A. Y.， W. THOMAS， K. H. SCHMITZ， M. S. KURZER。16周运动可降低年轻女性的c反应蛋白水平。医学科学。体育Exerc。，第43卷第6期，第1002-1009页，2011年。目的：有规律的运动已被证明可以预防乳腺癌的风险，其中一个可能的机制是通过减少炎症。本研究的目的是检查16周有氧运动训练对健康年轻女性脂肪因子和炎症标志物的影响。方法：参与者为319名年龄在18-30岁、身体质量指数在18-40 kg.m（-2）之间久坐不动的女性，随机分为运动干预组和不运动组，时间约为16周。在基线和16周后测量脂联素、瘦素、c反应蛋白（CRP）和淀粉样蛋白A （AA）。脂联素采用酶联免疫吸附法测定，AA、CRP和瘦素采用多重头阵列法测定。结果：与对照组相比，运动组CRP水平显著降低（-1.41 mg）。运动者的L-1 vs -0.005 mg。L-1在对照组中，P = 0.040)，这种影响主要是由肥胖锻炼者体内CRP的变化所驱动的。运动对SAA、脂联素和瘦素的水平没有影响。运动对压力和抑郁得分也没有影响。体脂百分比的变化和健康状况的变化都没有影响运动对这些炎症标志物的影响。结论：这项研究表明，16周的有氧运动计划显著降低了年轻女性的CRP水平，尤其是那些肥胖女性。没有证据表明这种影响是由感知压力、体脂百分比或健康状况的变化所介导的。这些发现表明，在生命早期养成锻炼习惯可能会降低肥胖女性未来患乳腺癌和其他慢性疾病的风险。
ARIKAWA, A. Y., W. THOMAS, K. H. SCHMITZ, and M. S. KURZER. Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women. Med. Sci. Sports Exerc., Vol. 43, No. 6, pp. 1002-1009, 2011. Purpose: Regular exercise has been shown to protect against breast cancer risk, and one possible mechanism is through a reduction in inflammation. The purpose of this study was to examine the effects of 16 wk of aerobic exercise training on adipokines and inflammatory markers in healthy young women. Methods: Participants were 319 sedentary women aged 18-30 yr, with body mass index of 18-40 kg.m(-2), randomized to an exercise intervention or no exercise for approximately 16 wk. Adiponectin, leptin, C-reactive protein (CRP), and amyloid A (AA) were measured at baseline and after 16 wk. Adiponectin was measured by enzyme-linked immunosorbent assay, and AA, CRP, and leptin were measured by multiplex bead array assays. Results: Exercise significantly decreased CRP levels in the exercise group compared with the control group (-1.41 mg.L-1 in exercisers vs -0.005 mg.L-1 in controls, P = 0.040), and this effect was largely driven by changes in CRP that occurred in the obese exercisers. There was no effect of exercise on levels of SAA, adiponectin, or leptin. There was also no effect of exercise on stress and depression scores. Neither change in percent body fat nor change in fitness influenced the effects of exercise on these inflammatory markers. Conclusions: This study demonstrated that a 16-wk aerobic exercise program significantly decreased levels of CRP in young women, especially in those who were obese. There was no evidence that this effect was mediated by changes in perceived stress, percent body fat, or fitness. These findings suggest that adopting an exercise routine early in life may decrease future risk of breast cancer and other chronic diseases in obese women.