Methamphetamine differentially regulates hippocampal glucocorticoid and mineralocorticoid receptor rnRNAs in Fischer and Lewis rats
Methamphetamine differentially regulates hippocampal glucocorticoid and mineralocorticoid receptor rnRNAs in Fischer and Lewis rats
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DOI：
10.1016/s0169-328x(03)00257-2
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发表时间：
2003-09-10
期刊：
影响因子：
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通讯作者：
Sato, M
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文献类型：
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作者：
Kabbaj, M;Yoshida, S;Sato, M
Fischer 344（F344）和刘易斯（LEW）大鼠在边缘-下丘脑-垂体-肾上腺（LHPA）轴的生理调节方面不同，使得F344大鼠对各种刺激表现出更大的LHPA轴反应。此外，LHPA轴的活动已经牵连到滥用药物的敏感性的发展，和F344大鼠表现出更大的行为敏感性精神兴奋剂。因此，我们假设，可能有一些重叠的神经生物学机制，这些应变LHPA轴活动的差异和行为敏感性的精神兴奋剂。我们研究了急性和重复甲基苯丙胺（4 mg/kg）治疗对F344和LEW大鼠海马糖皮质激素受体（GR mRNA）和盐皮质激素受体（MR mRNA）调节的影响。我们的研究结果表明，急性治疗甲基苯丙胺（MAP）不改变GR或MR mRNA的表达水平在这两个菌株。然而，MAP重复处理降低海马GR的表达，但不是MR mRNA特异性在F344大鼠。相同的重复处理对LEW大鼠的GR或MR mRNA均无影响。F344中海马GR mRNA表达水平的这种选择性MAP调节表明，这些受体可能在该品系对MAP的行为敏化的发展中发挥作用。海马GR mRNA在LEW大鼠中缺乏改变，表明海马GR的可塑性可能不是该品系中MAP行为敏感化发展的关键。(C)2003 Elsevier B. V.保留所有权利。
Fischer 344 (F344) and Lewis (LEW) rats differ in physiological regulation of the limbic-hypothalamo-pituitary-adrenal (LHPA) axis, such that F344 rats exhibit greater LHPA axis responses to a variety of stimuli. Furthermore, LHPA axis activity has been implicated in the development of sensitization to abused drugs, and F344 rats exhibit greater behavioral sensitization to psychostimulants. Accordingly, we hypothesized that there may be some overlap between the neurobiological mechanisms that underlie these strain differences in LHPA axis activity and in behavioral sensitization to psychostimulants. We examined the effects of acute and repeated methamphetamine (4 mg/kg) treatments on the regulation of hippocampal glucocorticoid receptors (GR mRNA) and mineralocorticoid receptors (MR mRNA) in F344 and LEW rats. Our results showed that acute treatment with methamphetamine (MAP) does not alter the level of expression of GR or MR mRNA in both strains. However, repeated treatments with MAP decreased the expression of hippocampal GR, but not MR mRNA specifically in F344 rats. The same repeated treatments had no effect on either GR or MR mRNA in LEW rats. This selective MAP regulation of the level of expression of hippocampal GR mRNA in F344 suggests that these receptors may play a role in the development of behavioral sensitization to MAP in this strain. The lack of alteration in hippocampal GR mRNA in LEW rats suggests that plasticity of hippocampal GR may not be critical for the development of behavioral sensitization to MAP in this strain. (C) 2003 Elsevier B.V. All rights reserved.