Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory:: Involvement of 5-HT1A receptors in the dorsal hippocampus in rats
Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory:: Involvement of 5-HT1A receptors in the dorsal hippocampus in rats
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DOI：
10.1016/j.brainres.2005.10.103
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发表时间：
2006-01-19
期刊：
影响因子：
2.9
通讯作者：
Fujiwara, M
中科院分区：
文献类型：
--
作者：
Egashira, N;Yano, A;Fujiwara, M
本研究的目的是确定介导的8-羟基-2-（二-eta-丙基氨基）四氢萘（8-OH-DPAT），5-HT 1A/5-HT 7受体激动剂，在八臂径向迷宫的大鼠空间记忆损伤的机制。WAY-100635和NAN-190，5-HT 1A受体拮抗剂，逆转了全身注射8-OH-DPAT（1 mg/kg，i. p.）诱导的空间记忆损伤。另一方面，α（1）-肾上腺素受体拮抗剂哌唑嗪和选择性5-HT 7受体拮抗剂SB 269970对8-OH-DPAT诱导的空间记忆障碍没有影响。双侧微量注射8-OH-DPAT（4 μ g/侧）时，注射到背侧海马（DH）的空间记忆受损。相比之下，空间记忆不受8-OH-DPAT微量注射到其他六个领域的研究：腹侧海马（VH），中央杏仁核（ACE），外侧下丘脑（LH），丘脑核（NAc），背侧（DR）和中间（MR）中缝核。此外，NAN-190显著逆转由DH内注射8-OH-DPAT诱导的空间记忆损伤。这些结果表明，5-HT 1A受体在8-OH-DPAT诱导的大鼠空间记忆障碍的机制中起重要作用。
The purpose of this study was to identify mechanisms that mediate the impairment of spatial memory induced by 8-hydroxy-2-(di-eta-propylamino)tetralin (8-OH-DPAT), a 5-HT1A/5-HT7 receptor agonist, in the eight-arm radial maze in rats. WAY-100635 and NAN-190, 5-HT1A receptor antagonists, reversed the impairment of spatial memory induced by systemic injection of 8-OH-DPAT (1 mg/kg, i.p.). On the other hand, the alpha(1)-adrenoceptor antagonist prazosin and a selective 5-HT7 receptor antagonist SB269970 had no effect on 8-OH-DPAT-induced impairment of spatial memory. Bilateral microinjection of 8-OH-DPAT (4 mu g/side) impaired spatial memory when injected into the dorsal hippocampus (DH). Contrastingly, spatial memory was unaffected by microinjections of 8-OH-DPAT into the other six areas examined: ventral hippocampus (VH), central amygdaloid nucleus (ACE), lateral hypothalamus (LH), nucleus accumbens (NAc), and dorsal (DR) and median (MR) raphe nucleus. Furthermore, NAN-190 significantly reversed the impairment of spatial memory induced by intra-DH injection of 8-OH-DPAT. These findings suggest that 5-HT1A receptors in the DH play an important role in the mechanisms underlying the 8-OH-DPAT-induced impairment of spatial memory in rats.