Malaria -: Cooperative silencing elements in var genes
Malaria -: Cooperative silencing elements in var genes
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DOI：
10.1038/35091146
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发表时间：
2001-08-30
期刊：
影响因子：
64.8
通讯作者：
Wellems, TE
中科院分区：
文献类型：
--
作者：
Deitsch, KW;Calderwood, MS;Wellems, TE
每一种恶性疟原虫携带来自不同家族的50个变异基因，这些基因编码宿主受感染红细胞上的可变粘附蛋白，在这里，我们表明这种沉默是在细胞周期的DNA合成期（S期）建立的，并且它依赖于每个可变基因的单独控制区（5′-侧翼区和内含子）中的两个元件之间的协同相互作用。这一发现将有助于阐明寄生虫协调变异基因沉默和激活的机制，这些变异基因是疟疾抗原变异的原因。
EachPlasmodium falciparummalaria parasite carries about 50vargenes from a diverse family that encode variable adhesion proteins on the infected red blood cells of the host,,, but individual parasites single out just onevargene for expression and silence all the others,. Here we show that this silencing is established during the DNA-synthesis phase (S phase) of the cell cycle and that it depends on the cooperative interaction between two elements in separate control regions of eachvargene (the 5′-flanking region and the intron). This finding should help to clarify the mechanisms by which parasites coordinate the silencing and activation ofvargenes that are responsible for antigenic variation in malaria.