Cell lines derived from pancreatic islets
Cell lines derived from pancreatic islets
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DOI：
10.1016/j.mce.2004.04.017
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发表时间：
2004-12-30
影响因子：
4.1
通讯作者：
Newgard, CB
中科院分区：
文献类型：
--
作者：
Hohmeier, HE;Newgard, CB
胰岛在控制代谢燃料体内平衡中起主要作用。全球糖尿病发病率的迅速增加激发了人们对胰岛细胞生物学的新兴趣。然而，在分子和生物化学水平上获得对胰岛功能的详细了解已经被与胰岛分离相关的困难和高成本所复杂化。直到最近，胰岛衍生的细胞系由于其未分化或不稳定的表型特征而代表了用于功能研究的原代细胞的次优替代物。新的方法已经导致啮齿动物胰岛素瘤细胞系的分离和表征，其保留了正常胰岛的许多关键功能属性，并且已经成为胰岛细胞生物学研究中的有用工具。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
The islets of Langerhans play a major role in control of metabolic fuel homeostasis. The rapid increase in incidence of diabetes worldwide has spurred renewed interest in islet cell biology. However, gaining a detailed understanding of islet function at a molecular and biochemical level has been complicated by the difficulty and high cost associated with isolation of pancreatic islets. Until recently, islet-derived cell lines have represented sub-optimal surrogates for primary cells for functional studies due to their undifferentiated Or unstable phenotypic features. New approaches have resulted in isolation and characterization of rodent insulinoma cell lines that retain many key functional attributes of normal islets and have become useful tools in the study of islet cell biology. (c) 2004 Elsevier Ireland Ltd. All rights reserved.