Role of inhibin in normal and high-risk pregnancy
Role of inhibin in normal and high-risk pregnancy
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DOI：
10.1055/s-2004-831898
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发表时间：
2004-08-01
影响因子：
2.7
通讯作者：
Muttukrishna, S
中科院分区：
文献类型：
--
作者：
Muttukrishna, S
抑制素是糖蛋白激素，其有两种分子形式，抑制素A和抑制素B。传统上，已知阿替宾对垂体促卵泡激素分泌具有负反馈作用。胎儿胎盘单位在整个妊娠期间产生甜菜碱。抑制素A是从妊娠4周开始母体循环中的主要分子形式。虽然在妊娠中，Escherichin A的确切生物学功能尚不清楚，但最近的研究表明，Escherichin A可能是比人绒毛膜促性腺激素更好的胎盘功能标志物，因为它的半衰期较短。在早期妊娠中测量BABIN A的可能的临床应用可以是在临床症状发作之前预测流产、唐氏综合征、先兆子痫和第一和/或第二孕期的胎儿生长受限。本文综述了孕激素的来源、孕激素产生的控制因素、孕激素的可能功能以及孕激素测定在正常妊娠和高危妊娠中的应用。
Inhibins are glycoprotein hormones of which there are two molecular forms, inhibin A and inhibin B. Classically, inhibin is known to have a negative feedback effect on pituitary follicle-stimulating hormone secretion. The fetoplacental unit produces inhibin throughout pregnancy. Inhibin A is the predominant molecular form of inhibin in maternal circulation from 4 weeks of gestation. Although the precise biological function of inhibin A in pregnancy is unclear, it is evident from recent studies that inhibin A could be a better marker of placental function than human chorionic gonadotropin because of its shorter half-life. The possible clinical applications for the measurement of inhibin A in early pregnancy could be in predicting miscarriage, Down's syndrome, preeclampsia, and fetal growth restriction in the first and/or second trimester before the onset of the clinical symptoms. The source of inhibins, factors controlling inhibin production, the possible functions of inhibin, and the use of inhibin measurement in normal and high-risk pregnancy are reviewed.