Hydrostatic fluid pressure in the vestibular organ of the guinea pig
Hydrostatic fluid pressure in the vestibular organ of the guinea pig
复制标题
豚鼠前庭器官的静水压力
DOI：
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发表时间：
2012
影响因子：
2.6
通讯作者：
M. Westhofen
中科院分区：
文献类型：
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作者：
J. Park;Jahn J. Boeven;Stefan Vogel;S. Leonhardt;H. Wit;M. Westhofen
由于内耳毛细胞是机械-电转换器，因此控制内耳中的静水压力是至关重要的。大多数分析内耳静水压力的动力学和调节的研究在耳蜗中进行压力测量。本研究是第一个报告的绝对静水压力值的迷宫。在所有三个半规管中记录内淋巴系统的静水压力。后半规管平均压力值为4.06 cmH 2 O ± 0.61，前半规管平均压力值为3.36 cmH 2 O ± 0.94，外半规管平均压力值为3.85 cmH 2 O ± 1.38。前庭器官的总体流体静压为3.76 cmH 2 O ± 0.36。所有三个半规管的内淋巴静水压力相同（p = 0.310）。关于过去研究中已知的耳蜗内淋巴压值，前庭压值与耳蜗值相当。内淋巴系统中最靠西的两个通道--集合管和Bast阀是开放还是关闭的，目前尚不清楚。目前的数据表明，最有可能的内淋巴系统是一个功能开放的实体。
Since inner ear hair cells are mechano-electric transducers the control of hydrostatic pressure in the inner ear is crucial. Most studies analyzing dynamics and regulation of inner ear hydrostatic pressure performed pressure measurements in the cochlea. The present study is the first one reporting about absolute hydrostatic pressure values in the labyrinth. Hydrostatic pressure of the endolymphatic system was recorded in all three semicircular canals. Mean pressure values were 4.06 cmH2O ± 0.61 in the posterior, 3.36 cmH2O ± 0.94 in the anterior and 3.85 cmH2O ± 1.38 in the lateral semicircular canal. Overall hydrostatic pressure in the vestibular organ was 3.76 cmH2O ± 0.36. Endolymphatic hydrostatic pressure in all three semicircular canals is the same (p = 0.310). With regard to known endolymphatic pressure values in the cochlea from past studies vestibular pressure values are comparable to cochlear values. Until now it is not known whether the reuniens duct and the Bast’s valve which are the narrowest passages in the endolymphatic system are open or closed. Present data show that most likely the endolymphatic system is a functionally open entity.