Hereditary carcinoma of the ovary and associated cancers: a study of two families.
Hereditary carcinoma of the ovary and associated cancers: a study of two families.
复制标题
遗传性卵巢癌及相关癌症：两个家庭的研究。
DOI：
10.1016/0090-8258(90)90107-v
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发表时间：
1990
影响因子：
4.7
通讯作者：
Lynch,J
中科院分区：
文献类型：
--
作者：
Lynch,HT;Fitzsimmons,ML;Conway,TA;Bewtra,C;Lynch,J
宿主因素在卵巢癌病因学中的作用越来越受到重视。病例/对照研究表明，在受卵巢癌影响的原系亲属中，这种疾病的发病率明显过高。系谱研究表明，其发生在特定部位的基础上，与乳腺癌（乳腺/卵巢癌综合征）和其他遗传性疾病有关。这种异质性的复杂性显然需要更深入的家庭研究。我们已经描述了遗传和临床病理的细微差别在两个扩大卵巢癌易发家族。由于缺乏预示癌症易感基因型的前兆生理印记和/或生物标志物，医生必须利用家谱中的最佳位置来识别那些患卵巢癌和/或综合征相关癌症的风险极高的患者，从而使监测策略更加集中。由于目前卵巢癌早期发现的监测策略的局限性，临床医生的责任包括确定和咨询预防性卵巢切除术的候选人。
Increasing attention has been given to host factors in the etiology of ovarian carcinoma. Case/control studies have shown a significant excess of this disease among primary relatives of ovarian cancer affecteds. Pedigree studies have demonstrated its occurrence on a site-specific basis, in association with carcinoma of the breast (breast/ovarian carcinoma syndrome), and in other hereditary disorders. The complexity of this heterogeneity clearly warrants more intensive family studies. We have described genetic and clinicopathologic nuances in two extended ovarian cancerprone families. The absence of premonitory physical stigmata and/or biomarkers which signify the cancer-prone genotype compels the physician to employ the best posits from the pedigree to identify those patients who are at inordinately high risk for ovarian and/or syndrome-associated cancer so that surveillance strategies can be more focused. Because of limitations of current surveillance strategies for the early detection of ovarian carcinoma, the clinician's responsibility includes the identification and counseling of candidates for prophylactic oophorectomy.