Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans.
Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans.
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DOI：
10.1088/1741-2552/ab8342
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发表时间：
2020-06-12
影响因子：
4
通讯作者：
Pérez Fornos A
中科院分区：
文献类型：
--
作者：
Crétallaz C;Boutabla A;Cavuscens S;Ranieri M;Nguyen TAK;Kingma H;Van De Berg R;Guinand N;Pérez Fornos A
探索不同电刺激曲线对Geneva-Maastricht前庭植入物原型的人类接受者的影响。本研究招募了4例植入患者。我们研究了电刺激轮廓（相位持续时间，脉冲频率，基线水平，调制深度）的系统变化在唤起前庭眼（eVOR）和知觉反应的相对功效。较短的相位持续时间，并在较小程度上，较慢的脉搏率允许最大限度地提高电动态范围可用于引发更广泛的强度前庭感知。当每个相持续时间或脉冲频率保持恒定时，电流调制深度是对eVOR的峰值速度具有最显著影响的因素。我们的结果确定了影响测量响应的重要参数变化。此外，我们观察到，当电极放置在半规管中并使用单极刺激时，并非所有前庭通路似乎对电刺激都同样敏感。这为评估前庭植入物的新刺激策略打开了大门，并表明有可能选择性地激活一条前庭通路或另一条，以优化康复结果。
To explore the impact of different electrical stimulation profiles in human recipients of the Geneva-Maastricht vestibular implant prototypes. Four implanted patients were recruited for this study. We investigated the relative efficacy of systematic variations of the electrical stimulus profile (phase duration, pulse rate, baseline level, modulation depth) in evoking vestibulo-ocular (eVOR) and perceptual responses. Shorter phase durations and, to a lesser extent, slower pulse rates allowed maximizing the electrical dynamic range available for eliciting a wider range of intensities of vestibular percepts. When each either phase duration or pulse rate was held constant, current modulation depth was the factor that had the most significant impact on peak velocity of the eVOR. Our results identified important parametric variations that influence the measured responses. Furthermore, we observed that not all vestibular pathways seem equally sensitive to the electrical stimulus when the electrodes are placed in the semicircular canals and monopolar stimulation is used. This opens the door to evaluating new stimulation strategies for a vestibular implant, and suggests the possibility of selectively activating one vestibular pathway or the other in order to optimize rehabilitation outcomes.