Rational Design of Polyphenol-Poloxamer Nanovesicles for Targeting Inflammatory Bowel Disease Therapy
Rational Design of Polyphenol-Poloxamer Nanovesicles for Targeting Inflammatory Bowel Disease Therapy
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用于靶向治疗炎症性肠病的多酚泊洛沙姆纳米囊泡的合理设计
DOI：
10.1021/acs.chemmater.8b01173
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发表时间：
2018
影响因子：
8.6
通讯作者：
Yang Min
中科院分区：
文献类型：
--
作者：
Wang Xinyu;Yan Jun-Jie;Wang Lizhen;Pan Donghui;Yang Runlin;Xu YuPing;Sheng Jie;Huang Qianhuan;Zhao Huimin;Yang Min
目前，炎症性肠病（IBD）还没有治愈性治疗方法，炎症性肠病（IBD）的结肠炎相关癌症风险增加。糖皮质激素是IBD的主要临床治疗药物，但具有显著的副作用。即使大量使用皮质类固醇也可能导致IBD治疗失败，这可能导致切除手术。本研究设计了一种新型抗炎激素地塞米松（DEX）给药系统（DDS），用于IBD的治疗。该DDS是通过天然安全的多酚和聚合物的氢键诱导的简易自组装来筛选的。由单宁酸和Pluronic F-68制备的纳米颗粒具有均匀的球形形状。在约10%DEX负载的情况下，PPNP-DEX在酯酶存在下显示出响应性释放行为。此外，PPNP-DEX在炎症部位的自由基清除方面表现出很大的潜力。与健康对照组相比，结肠炎小鼠的药物保留率也可以提高，因为这种炎症反应可能会导致结肠炎。
Currently, there is no curative treatment for inflammatory bowel disease (IBD), which has an increased risk of colitis-associated cancer. Corticosteroids are the main clinical IBD therapeutics but have significant side effects. Even heavy corticosteroid use can result in the failure of IBD treatment which may lead to resective surgery. In this study, we designed one type of new drug-delivery system (DDS) delivering dexamethasone (DEX), an anti-inflammation corticosteroid, for IBD therapy. This DDS was screened by hydrogen-bonding-induced facile self-assembly of natural and safe polyphenols and polymers. The nanoparticles fabricated from tannic acid and Pluronic F-68 have a uniform spherical shape. With approximately 10% DEX loaded, PPNP-DEX showed responsive release behavior in the presence of esterase. Moreover, PPNP-DEX exhibited great potential in radical scavenging at inflammation sites. Drug retention rates can also be enhanced in mice with colitis compared with healthy controls because of this infla...