Race/ethnicity moderates the relationship between depressive symptom severity and C-reactive protein: 2005-2010 NHANES data
Race/ethnicity moderates the relationship between depressive symptom severity and C-reactive protein: 2005-2010 NHANES data
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DOI：
10.1016/j.bbi.2014.04.004
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发表时间：
2014-10-01
影响因子：
15.1
通讯作者：
Stewart, Jesse C.
中科院分区：
文献类型：
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作者：
Case, Stephanie M.;Stewart, Jesse C.
由于很少有研究探讨抑郁症方面或抑郁症-炎症关系的潜在调节因素，我们的目的是确定特定的抑郁症状群是否与C反应蛋白（CRP）水平更密切相关，以及种族/民族是否调节这些关系。我们检查了来自10，149名代表美国人口的成年人的数据（4858名非西班牙裔白色，1978名非西班牙裔黑人，2260名墨西哥裔美国人，1053名其他西班牙裔），他们参加了2005年至2010年的全国健康和营养检查调查。抑郁症状通过患者健康问卷-9进行评估，高灵敏度血清CRP通过乳胶增强散射比浊法进行定量。在个体模型中，总体（p <0.001）、躯体（p <0.001）和非躯体（p = 0.001）抑郁症状均与血清CRP呈正相关。然而，在同时包括两个症状群的模型中，躯体症状（p <0.001），而非躯体症状（p = 0.98），仍然与血清CRP相关。还观察到种族/民族的适度证据，因为九种抑郁症状中的六种x种族/民族相互作用是显著的（ps < .05）。在非西班牙裔白人中，结果模式与全部样本相同;在同步模型中，仅躯体症状（p <0.001）与血清CRP相关。在非西班牙裔黑人、墨西哥裔美国人或其他西班牙裔人群中，未观察到总体、躯体或非躯体症状与血清CRP之间的关系。我们的研究结果表明，抑郁症状和全身性炎症之间的联系可能是由于睡眠障碍，疲劳，食欲变化和精神发育迟滞/激动的躯体症状，可能是最强的非西班牙裔白人。(C)2014爱思唯尔公司All rights reserved.
Because few studies have examined depression facets or potential moderators of the depression-inflammation relationship, our aims were to determine whether particular depressive symptom clusters are more strongly associated with C-reactive protein (CRP) levels and whether race/ethnicity moderates these relationships. We examined data from 10,149 adults representative of the U.S. population (4858 non-Hispanic White, 1978 non-Hispanic Black, 2260 Mexican American, 1053 Other Hispanic) who participated in the cross-sectional National Health and Nutrition Examination Survey between 2005 and 2010. Depressive symptoms were assessed by the Patient Health Questionnaire-9, and high-sensitivity serum CRP was quantified by latex-enhanced nephelometry. Total (p < .001), somatic (p < .001), and nonsomatic (p = .001) depressive symptoms were each positively related to serum CRP in individual models. However, in the simultaneous model that included both symptom clusters, somatic symptoms (p < .001), but not nonsomatic symptoms (p = .98), remained associated with serum CRP. Evidence of moderation by race/ethnicity was also observed, as six of the nine depressive symptoms x race/ethnicity interactions were significant (ps < .05). Among non-Hispanic Whites, the pattern of results was identical to the full sample; only somatic symptoms (p < .001) remained related to serum CRP in the simultaneous model. No relationships between total, somatic, or nonsomatic symptoms and serum CRP were observed among the non-Hispanic Black, Mexican American, or Other Hispanic groups. Our findings indicate that the link between depressive symptoms and systemic inflammation may be due to the somatic symptoms of sleep disturbance, fatigue, appetite changes, and psychomotor retardation/agitation and may be strongest among non-Hispanic Whites. (C) 2014 Elsevier Inc. All rights reserved.