Ferulic acid increases intestinal Lactobacillus and improves cardiac function in TAC mice
Ferulic acid increases intestinal Lactobacillus and improves cardiac function in TAC mice
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阿魏酸可增加 TAC 小鼠肠道乳酸菌并改善心脏功能。
DOI：
10.1016/j.biopha.2019.109482
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发表时间：
2019-12-01
影响因子：
7.5
通讯作者：
Xu, Dingli
中科院分区：
文献类型：
--
作者：
Liu, Zuheng;Ma, Zhuang;Xu, Dingli
阿魏酸是川乌的主要成分，在心脏病中具有抗氧化和抗炎作用。一些研究表明，肠道微生物群与阿魏酸的产生有关。阿魏酸的有益作用是否通过肠道微生物区系的改变而提高，目前尚不清楚。本研究观察了阿魏酸钠对TAC小鼠肠道菌群和心功能的影响。细胞计数试剂盒8(CCK8)实验证实阿魏酸体外毒性低，可抑制血管紧张素II诱导的β-MHC和ANP的上调。此外，每天补充50 mg/kg阿魏酸钠可改善TAC小鼠的射血分数和肠道微生物区系组成。用阿魏酸钠灌胃的TAC小鼠乳杆菌和类副杆菌的相对丰度增加。乳酸菌与HW/BW、LW/BW呈负相关。这些结果表明，阿魏酸对TAC小鼠的有益作用可能是通过调节肠道微生物区系实现的。
Ferulic acid, a main ingredient of Ligusticum, exhibits anti-oxidant and anti-inflammation effects in heart diseases. Some studies indicate that gut microbiome is associated with the generation of ferulic acid. Whether the beneficial effect of ferulic is raised by the alteration of gut microbiota is still unknown. This study examined the effect of sodium ferulate on gut microbiome and cardiac function in TAC mice. Cell Counting Kit-8 (CCK8) assay verified that ferulic acid has low toxicity in vitro and that ferulic acid inhibited the up-regulation of beta-MHC and ANP induced by Angiotensin II. In addition, daily supplement of 50 mg/kg sodium ferulate improved the ejection fraction and changed the gut microbiota composition of TAC mice. Relative abundance of Lactobacillus and Parabacteroides are increased in TAC mice gavaged with sodium ferulate. In addition, Lactobacillus is negatively correlated with HW/BW and LW/BW ratio. These results suggest that the beneficial effect of ferulic in TAC mice is probably through the regulation of gut microbiota.