Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial.
Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial.
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低饱和脂肪、低胆固醇鱼油补充剂对高甘油三酯血症患者的影响。
DOI：
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发表时间：
1988
影响因子：
39.2
通讯作者：
B. Johnson
中科院分区：
文献类型：
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作者：
William S. Harris;C. Dujovne;Marjorie L Zucker;B. Johnson
研究目的
探讨低饱和脂肪和低胆固醇鱼油补充剂对高脂血症患者血脂和脂蛋白水平的影响。
设计
单盲、安慰剂对照（红花油）、交叉试验，治疗期为6周。
设置
一所大学医学中心的血脂门诊。
患者
11例成人患者有孤立性高胆固醇血症（IV型），7例伴有高胆固醇血症（IIb型）。
干预
在每个治疗阶段，每天服用12粒1 g鱼油或安慰剂（红花油）胶囊。
测量值和主要结果
在每个阶段的第5周和第6周抽血，分析总脂质;极低、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）中的胆固醇（mmol/L）;和载脂蛋白B（mg/dL）。与安慰剂相比，鱼油降低了血浆甘油三酯水平（4.0 +/- 1.8至2.5 +/- 1.0），并提高LDL胆固醇水平（3.7 +/- 1.75至4.25 +/- 0.85），载脂蛋白B水平（122 +/- 29至140 +/- 34），以及LDL胆固醇与HDL胆固醇的比值（4.0 +/- 0.9至4.7 +/- 1.4）（P <0.05;平均值+/- SD）。HDL或HDL胆固醇亚组分水平无显著变化。在具有IIb型和IV型脂蛋白表型的患者中观察到类似的反应。
结论
因为鱼油补充剂对饮食中的胆固醇和饱和脂肪的贡献可以忽略不计，所以n-3脂肪酸最有可能引起观察到的影响。这些发现表明，相对少量的鱼油可以对高脂血症患者的血浆甘油三酯水平产生有益的影响，但LDL胆固醇和载脂蛋白B水平的增加，以及LDL胆固醇与HDL胆固醇的比值表明，需要仔细监测鱼油补充期间血浆脂蛋白的变化，并仔细评估其长期益处。
STUDY OBJECTIVE
To determine the effects of fish oil supplements low in saturated fat and cholesterol on plasma lipid and lipoprotein levels in hypertriglyceridemic patients.
DESIGN
Single-blind, placebo-controlled (safflower oil), crossover trial with 6-week treatment periods.
SETTING
Outpatient lipid clinic in a university medical center.
PATIENTS
Eleven adult patients had isolated hypertriglyceridemia (type IV) and seven had concomitant hypercholesterolemia (Type IIb).
INTERVENTION
Twelve 1-g capsules of either fish oil or placebo (safflower oil) were taken daily during each treatment period.
MEASUREMENTS AND MAIN RESULTS
Blood was drawn at the fifth and sixth week of each period and analyzed for total lipids; cholesterol in very low, low (LDL), and high density (HDL) lipoproteins (mmol/L); and apoprotein B (mg/dL). Compared with the placebo, fish oil lowered plasma triglyceride levels (4.0 +/- 1.8 to 2.5 +/- 1.0), and raised LDL cholesterol levels (3.7 +/- 1.75 to 4.25 +/- 0.85), apolipoprotein B levels (122 +/- 29 to 140 +/- 34), and the ratio of LDL cholesterol to HDL cholesterol (4.0 +/- 0.9 to 4.7 +/- 1.4) (P less than 0.05; mean +/- SD). No significant changes were seen in levels of HDL or HDL cholesterol subfractions. Similar responses were seen in patients with both type IIb and IV lipoprotein phenotypes.
CONCLUSIONS
Because the fish oil supplement contributed negligible amounts of cholesterol and saturated fat to the diet, the n-3 fatty acids most likely caused the observed effects. These findings indicate that relatively small amounts of fish oil can have beneficial effects on plasma triglyceride levels in hypertriglyceridemic patients, but the increase in LDL cholesterol and apoprotein B levels, and in the LDL cholesterol to HDL cholesterol ratio suggests the need for careful monitoring of plasma lipoprotein changes during fish oil supplementation, and for a careful evaluation of their long-term benefits.