HIV type 1 subtypes among STI patients in Nairobi:: A genotypic study based on partial pol gene sequencing
HIV type 1 subtypes among STI patients in Nairobi:: A genotypic study based on partial pol gene sequencing
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DOI：
10.1089/aid.2006.22.1172
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发表时间：
2006-11-01
影响因子：
1.5
通讯作者：
Songok, Elijah M.
中科院分区：
文献类型：
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作者：
Lihana, Raphael W.;Khamadi, Samoel A.;Songok, Elijah M.
人类免疫缺陷病毒（HIV）的循环株表现出非凡的遗传多样性，并已根据关系分为不同的谱系，称为组，类型，亚型和亚亚型。性传播感染（STI）是已知的艾滋病毒感染的风险因素。为了确定内罗毕性病患者中HIV-1亚型的多样性，收集了140份样本，并进行了部分pol基因测序。从分析中确定亚型A1是主要亚型（64%），其次是D（17%）、C（9%）、G（1%）和重组体AD（4%）、AC（3%）、CRF02_AG（1%）和CRF16_A2D（1%）。这些结果表明，HIV-1的流行可能会演变成更致命的和复杂的亚型，通过复杂的重组，由于病毒的混合传播。因此，在开始治疗和/或管理之前，任何抗逆转录病毒药物的使用都可能需要对新发耐药性进行初步检测。
Circulating strains of human immunodeficiency virus (HIV) exhibit an extraordinary degree of genetic diversity and have been classified on the basis of relationships into distinct lineages called groups, types, subtypes, and subsubtypes. Sexually transmitted infections (STIs) are known to be a risk factor for HIV infection. To establish HIV-1 subtype diversity among STI patients in Nairobi, 140 samples were collected and partial pol gene sequencing done. From the analysis it was established that subtype A1 was the major subtype (64%) followed by D (17%), C (9%), G (1%), and recombinants AD (4%), AC (3%), CRF02_AG ( 1%), and CRF16_A2D ( 1%). These results suggest that the HIV-1 epidemic may be evolving toward more virulent and complex subtypes through transmission of complex recombinants due to viral mixing. Any use of ARVs may therefore require initial testing for de novo resistance before commencement of treatment and/or management.