Neutrophil to lymphocyte ratio as a prognostic marker in metastatic gallbladder cancer
Neutrophil to lymphocyte ratio as a prognostic marker in metastatic gallbladder cancer
复制标题
DOI：
10.1016/j.hpb.2020.02.002
复制
发表时间：
2020-10-01
期刊：
影响因子：
2.9
通讯作者：
Mahipal, Amit
中科院分区：
文献类型：
--
作者：
Mady, Mohamed;Prasai, Kritika;Mahipal, Amit
背景：中性粒细胞与淋巴细胞比率（NLR）已被用作各种恶性肿瘤的炎症基础诊断标志物。本研究评价了转移性胆囊癌（GBC）患者的NLR与总生存期（OS）之间的关系。方法：通过绘制基于样条的风险比曲线来确定NLR的最佳截止点，以确定阈值效应。绘制Kaplan-Meier曲线，NLR >= 5和NLR= 5的患者的OS显著差于NLR = 5的患者，与NLR = 5相比，NLR = 5与更差的OS相关，NLR = 5是转移性GBC患者预后不良的独立预测因子。
Background: Neutrophil-to-lymphocyte ratio (NLR) has been used as an inflammation based prog-nostic marker for various malignancies. This study evaluated the association between NLR and overall survival (OS) in patients with metastatic gallbladder cancer (GBC)Methods: An optimal cut off point for NLR was identified by plotting spline-based hazard ratio curves to identify a threshold effect and patients were divided into two groups, 5. Kaplan-Meier curves were plotted for NLR >= 5 and NLR= 5 had a significantly poor OS compared to those with NLR = 5 was associated with a worse OS compared to NLR = 5 is an independent predictor of poor prognosis in patients with metastatic GBC.