Fluorescence excitation spectrum of bilirubin in blood: a model for the action spectrum for phototherapy of neonatal jaundice.

Fluorescence excitation spectrum of bilirubin in blood: a model for the action spectrum for phototherapy of neonatal jaundice.
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DOI:
10.1111/php.12167
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发表时间:
2014-03
影响因子:
3.3
通讯作者:
Russo M
Russo M
中科院分区:
生物学3区
文献类型:
--
作者:
Lamola AA;Russo M

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最近的一份报告(Lamola等人2013儿科研究,74,54-60)提出了一个半经验模型,用于使用最新的新生儿皮肤光学知识轻松计算体内胆红素光化学的作用光谱。计算表明,皮肤中的血红蛋白对光疗光的竞争是定义胆红素吸收的光光谱的主要因素。如果后者是正确的,那么计算出的光谱的有效物理模拟是血液中胆红素的激发光谱。记录了荧光激发光谱,确实发现与计算的光谱非常相似。这两个光谱都在476 nm附近出现最大值,半高处的宽度约为50 nm。这一结果支持了460~490 nm之间的光对新生儿黄疸的光治疗效果最好的结论。
A recent report (Lamola et al. 2013 Pediatric Research, 74, 54–60) presents a semi-empirical model for facile calculation of an action spectrum for bilirubin photochemistry in vivo using the most current knowledge of the optics of neonatal skin. The calculations indicate that competition for phototherapy light by hemoglobin in the skin is the predominant factor that defines the spectrum of light absorbed by bilirubin. If the latter is correct, a valid physical analog of the calculated spectrum is the excitation spectrum of bilirubin in blood. The fluorescence excitation spectrum was recorded and, indeed, found to be very similar to the calculated spectrum. Both spectra exhibit maxima near 476 nm and widths at half height of about 50 nm. This result supports the conclusion that light between 460 and 490 nm is most effective for phototherapy of neonatal jaundice.
DOI: 10.1542/peds.2011-1494
发表时间: 2011-10-01
期刊: PEDIATRICS
影响因子: 8
作者:
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