Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation
Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation
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DOI：
10.3892/ijmm_00000482
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发表时间：
2010-09-01
影响因子：
5.4
通讯作者：
Takeda, Kan
中科院分区：
文献类型：
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作者：
Beppu, Tetsuya;Sugimoto, Kazushi;Takeda, Kan
本研究的目的是阐明甲胎蛋白 (AFP)、甲胎蛋白 A 反应部分 (AFP-L3) 和脱伽马羧基凝血酶原 (DCP) 三种肿瘤标志物对于检测和预测肝细胞癌 (HCC) 复发的重要性。本研究共纳入 108 例在我院接受根治性射频消融（RFA）的初发非晚期 HCC 患者。分析了三种肿瘤标志物检测复发和无复发生存的有效性。这三个标记的阳性率在第一次或第二次复发时没有显着增加。此外，每种肿瘤标志物的初始水平和复发水平之间没有显着相关性。最初 HCC 时呈阳性的肿瘤标志物在复发时不一定呈阳性。复发时的肿瘤标志物水平与消融前的水平不相关。消融前的肿瘤标志物值与复发时间之间没有发现显着相关性。在多变量分析中，高 AFP-L3 水平 (>= 10%) 显着预测无复发生存。应常规测量所有三种肿瘤标志物，以检测 RFA 后随访期间的复发情况。尤其是高 AFP-L3 水平应密切关注。
The aim of this study was to elucidate the importance of three tumor markers, a-fetoprotein (AFP), Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP), for detecting and predicting the recurrence of hepatocellular carcinomas (HCCs). A total of 108 patients with initial non-advanced HCC who underwent curative radiofrequency ablation (RFA) in our hospital were enrolled in this study. The effectiveness of the three tumor markers for detecting recurrence and recurrence-free survival was analyzed. Positivity of these three makers was not markedly increased at the first or second recurrence. In addition, there was no significant correlation between the initial and recurrent levels of each tumor marker. The tumor marker that was positive at the time of initial HCC was not necessarily positive at recurrence. The tumor marker levels at recurrence were not correlated with pre-ablation levels. No significant correlation was found in the tumor marker values between pre-ablation and the time of recurrence. On multivariate analysis, high AFP-L3 levels (>= 10%) were significantly predictive of recurrence-free survival. All three tumor markers should be routinely measured to detect recurrence during follow-up after RFA. Especially high AFP-L3 levels should be followed closely.