Integrin αvβ3 is involved in stimulated migration of vascular adventitial fibroblasts by basic fibroblast growth factor but not platelet-derived growth factor
Integrin αvβ3 is involved in stimulated migration of vascular adventitial fibroblasts by basic fibroblast growth factor but not platelet-derived growth factor
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DOI：
10.1002/jcb.1208
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发表时间：
2001-01-01
影响因子：
4
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Liu, GZ;Eskin, SG;Mikos, AG
我们研究了碱性成纤维细胞生长因子（bFGF）和血小板衍生生长因子（PDGF）对大鼠主动脉外膜血管外膜成纤维细胞（VAFs）迁移的影响。bFGF和PDGF均能显著促进体外VAF迁移。针对大鼠β(3)整合素的抗体以剂量依赖的方式减少bfgf刺激的迁移。此外，在环状RGD （cRGD）肽的存在下，VAF的迁移受到抑制。然而，pdgf导向的迁移仅被等效的cRGD肽阻断，而不被β(3)整合素抗体阻断。这些数据表明，α (v) β(3)整合素介导bFGF刺激的VAF迁移，并且化学引诱剂定向迁移可能通过不同的整合素。j .细胞。生物化学学报，32 (3):559 - 557,2001,(C) 2001。
We examined the effects of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) on the migration of vascular adventitial fibroblasts (VAFs) isolated from rat aortic adventitiae. Both bFGF and PDGF significantly stimulated VAF migration in vitro. An antibody to rat beta (3) integrin reduced bFGF-stimulated migration in a dose dependent manner. Moreover, VAF migration was inhibited in the presence of cyclic RGD (cRGD) peptide. However, PDGF-directed migration was blocked only by equivalent cRGD peptide but not by antibody to beta (3) integrin. These data suggest that alpha (v)beta (3) integrin mediates VAF migration stimulated by bFGF and that chemoattractant directed migration may be through distinct integrins. J. Cell. Biochem. 83: 129-135, 2001, (C) 2001 Wiley-Liss, Inc.