Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection
Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection
复制标题
DOI：
10.1093/infdis/jiac053
复制
发表时间：
2022-03-14
影响因子：
6.4
通讯作者：
Sato, Kei
中科院分区：
文献类型：
--
作者：
Uriu, Keiya;Cardenas, Paul;Sato, Kei
SARS-CoV-2 Mu变体刺突中的两个突变，YY 144 - 145 TSN和E484 K，是对COVID-19恢复期和疫苗血清具有显著抗性的原因。SARS-CoV-2 Mu感染个体的恢复期血清对Mu以及其他variants.Background具有广泛的抗病毒性，我们最近发现严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）Mu变体显示出对天然SARS-CoV-2感染和疫苗接种引起的抗体的显著抗性。方法SARS-CoV-2 Mu对抗病毒血清的耐药性由哪些突变决定，目前尚不清楚。此外，目前还不清楚SARS-CoV-2 Mu感染如何诱导抗病毒免疫。结果SARS-CoV-2 Mu刺突蛋白中的2个突变YY 144 - 145 TSN和E484 K与2020年初期间的2019冠状病毒病恢复期血清和疫苗血清的抵抗有关。结论SARS-CoV-2 Mu感染者恢复期血清对Mu及其他SARS-CoV-2变异株具有广泛的抗病毒活性。
Two mutations in the SARS-CoV-2 Mu variant spike, YY144-145TSN and E484K, are responsible for the pronounced resistance to COVID-19 convalescent and vaccine sera. The convalescent sera of SARS-CoV-2 Mu-infected individuals are broadly antiviral against Mu as well as other variants.Background We have recently revealed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mu variant shows a pronounced resistance to antibodies elicited by natural SARS-CoV-2 infection and vaccination. Methods However, it remains unclear which mutations determine the resistance of SARS-CoV-2 Mu to antiviral sera. In addition, it is unclear how SARS-CoV-2 Mu infection induces antiviral immunity. Results In this study, we reveal that the 2 mutations in the SARS-CoV-2 Mu spike protein, YY144-145TSN and E484K, are responsible for the resistance to coronavirus disease 2019 convalescent sera during early 2020 and vaccine sera. Conclusions It is notable that the convalescent sera of SARS-CoV-2 Mu-infected individuals are broadly antiviral against Mu as well as other SARS-CoV-2 variants of concern and interest.