Effect of Iterative Reconstruction on the Detection of Systemic Sclerosis-related Interstitial Lung Disease: Clinical Experience in 55 Patients
Effect of Iterative Reconstruction on the Detection of Systemic Sclerosis-related Interstitial Lung Disease: Clinical Experience in 55 Patients
复制标题
DOI：
10.1148/radiol.2015150849
复制
发表时间：
2016-04-01
期刊：
影响因子：
19.7
通讯作者：
Remy-Jardin, Martine
中科院分区：
文献类型：
--
作者：
Pontana, Francois;Billard, Anne-Sophie;Remy-Jardin, Martine
目的：目的：评价放射剂量减少60%时迭代重建对系统性硬化症相关间质性肺疾病（ILD）显示的影响。材料和方法：本研究基于对12个月前瞻性采集数据的回顾性解释，并经机构审查委员会批准。豁免了获得知情同意书的要求。对38名女性和17名男性进行了55次胸部CT检查（平均年龄55.8岁;范围，23-82岁），使用双源CT装置，（a）两个管设置在相似的能量（120 kVp）和（B）总参考毫安秒（即，110 mAs）以40%施加到管A和60%施加到管B的方式分裂。从同一数据集同时生成两个系列的图像：（a）使用滤波反投影重建的标准剂量图像（从两个管生成）（组1，参考标准）和（B）使用正弦图确认迭代重建（SAFIRE）重建的减少剂量图像（从管A生成; 60%剂量减少）（组2）。在两组中，分析的参数包括图像噪声和ILD CT特征的可视化和显著性。两名阅片师独立分析两组图像，采用Wilcoxon检验对配对样本进行比较，适当时计算95%置信区间。结果：第2组的客观噪声平均水平显著低于第1组（分别为22.02 HU和26.23 HU; P < .0001）。第1组ILD的CT特征始终在第2组中描述，第2组中磨玻璃样阴影、网状影和支气管扩张和/或细支气管扩张的主观显著性评分（a）改善，（B）两组中蜂窝样改变的主观显著性评分相同。两组的观察者间描述一致性极佳（k，0.84-0.98）。结论：尽管剂量减少了60%，但与参考标准相比，SAFIRE重建的图像允许相似的系统性硬化相关ILD检测。(C)RSNA，2015年
Purpose: To evaluate the effect of iterative reconstruction on the depiction of systemic sclerosis-related interstitial lung disease (ILD) when the radiation dose is reduced by 60%.Materials and Methods: This study was based on retrospective interpretation of prospectively acquired data over a 12-month period and approved by the institutional review board. The requirement to obtain informed consent was waived. Fifty-five chest computed tomographic (CT) examinations were performed in 38 women and 17 men (mean age, 55.8 years; range, 23-82 years) by using a dual-source CT unit with (a) both tubes set at similar energy (120 kVp) and (b) the total reference milliampere seconds (ie, 110 mAs) split up in a way that 40% was applied to tube A and 60% to tube B. Two series of images were generated simultaneously from the same dataset: (a) standard-dose images (generated from both tubes) reconstructed with filtered back projection (group 1, the reference standard) and (b) reduced-dose images (generated from tube A; 60% dose reduction) reconstructed with sinogram-affirmed iterative reconstruction (SAFIRE) (group 2). In both groups, the analyzed parameters comprised the image noise and the visualization and conspicuity of CT features of ILD. Two readers independently analyzed images from both groups.Results were compared by using the Wilcoxon test for paired samples; the 95% confidence interval was calculated when appropriate. Results: The mean level of objective noise in group 2 was significantly lower than that in group 1 (22.02 HU vs 26.23 HU, respectively; P < .0001). The CT features of ILD in group 1 were always depicted in group 2, with subjective conspicuity scores (a) improved in group 2 for ground-glass opacity, reticulation, and bronchiectasis and/or bronchiolectasis and (b) identical in both groups for honeycombing. The interobserver agreement for their depiction was excellent in both groups (k, 0.84-0.98).Conclusion: Despite a 60% dose reduction, images reconstructed with SAFIRE allowed similar detection of systematic sclerosis-related ILD compared with the reference standard. (C) RSNA, 2015