Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.
Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.
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DOI：
10.7150/jca.11185
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发表时间：
2015
影响因子：
3.9
通讯作者：
Li YL
中科院分区：
文献类型：
--
作者：
Xi Y;Gao H;Callaghan MU;Fribley AM;Garshott DM;Xu ZX;Zeng Q;Li YL
天然的二芳基庚烷类姜黄素(Cur)是亚洲香料姜黄的主要成分，已被证明在许多肿瘤类型中具有抗癌作用。然而，关于Cur诱导肿瘤细胞杀伤的详细机制仍有待全面探讨。用头颈部鳞状细胞癌(HNSCC)细胞系FaDu(下咽)和Cal27(舌)，我们证明了一种新的细胞毒作用机制。我们发现，在Cur诱导细胞死亡的主要机制中，Cur诱导促凋亡的Bik表达上调，AKT和NF-κB在诱导caspase级联抑制细胞增殖之前下调生存信号，从而为研究Cur的抗肿瘤活性提供了新的思路。
Naturally occurring diarylheptanoid curcumin (CUR), a principal component of the Asian spice turmeric, has been shown to have anti-cancer effects in many tumor types. However, a detailed mechanism regarding CUR induced tumor cell killing remain to be comprehensively explored. Using two head neck squamous cell carcinoma (HNSCC) cell lines FaDu (hypopharyngeal) and Cal27 (tongue), we demonstrated a novel mechanism by which CUR levies the cytotoxic effect. We found that CUR induced upregulation of pro-apoptotic Bik, down-regulation of survival signaling by AKT and NF-κB prior to the induction of the caspase-cascade reduction of cell proliferation, are primary mechanisms of CUR-induced cell death, thus providing insights into the anti-tumor activity of CUR in HNSCC cells.
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影响因子：
3.7
作者：
Kumar B;Yadav A;Hideg K;Kuppusamy P;Teknos TN;Kumar P
通讯作者：
Kumar P
DOI：
10.1158/1078-0432.ccr-08-3252
发表时间：
2009-06-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Knowles LM;Stabile LP;Egloff AM;Rothstein ME;Thomas SM;Gubish CT;Lerner EC;Seethala RR;Suzuki S;Quesnelle KM;Morgan S;Ferris RL;Grandis JR;Siegfried JM
通讯作者：
Siegfried JM
影响因子：
4.8
作者：
Bossy-Wetzel, E;Green, DR
通讯作者：
Green, DR
受体酪氨酸激酶的可发展信号网络：鲁棒性与恶性肿瘤和癌症治疗的相关性。
影响因子：
9.9
作者：
Amit, Ido;Wides, Ron;Yarden, Yosef
通讯作者：
Yarden, Yosef
DOI：
10.1186/1758-3284-1-6
发表时间：
2009-03-02
期刊：
Head & neck oncology
影响因子：
--
作者：
Matta A;Ralhan R
通讯作者：
Ralhan R