Drug allergy
Drug allergy
复制标题
DOI：
10.1016/j.jaci.2009.10.028
复制
发表时间：
2010-02-01
影响因子：
14.2
通讯作者：
Solensky, Roland
中科院分区：
文献类型：
--
作者：
Khan, David A.;Solensky, Roland
药物过敏是药物不良反应的一种，涵盖一系列具有不同机制和临床表现的超敏反应。完整的病史对于药物过敏的管理至关重要。实验室检测在药物过敏管理中的作用非常有限。当药物过敏患者明确需要某种药物时，可能需要分级剂量挑战和诱导药物耐受的程序。将进一步详细讨论对特定药物（包括 β-内酰胺类抗生素、磺胺类药物、局部麻醉剂、放射造影剂、血管紧张素转换酶抑制剂、非甾体类抗炎药和生物调节剂）反应的管理。 （《过敏临床免疫杂志》2010 年；125：S126-37。）
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including beta-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail. (J Allergy Clin Immunol 2010;125:S126-37.)