Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese.
Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese.
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DOI：
10.1016/j.fct.2008.03.004
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
R. Yokel;C. L. Hicks;Rebecca L. Florence
中科院分区：
文献类型：
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作者：
R. Yokel;C. L. Hicks;Rebecca L. Florence
先前已经估计了来自饮用水的口服铝（Al）生物利用度，但是关于来自食物的Al生物利用度的信息很少。据认为，口服铝的生物利用度从饮用水是远远大于从食物。目的是进一步检验这一假设。口服铝的生物利用度测定大鼠从碱性[26铝]-磷酸铝钠（基本SALP）在加工奶酪。结果表明，每1g含1.5%或3%碱性SALP的干酪，其口服铝生物利用度（F）分别为0.1%和0.3%，血清26铝达峰时间（Tmax）为8- 9 h。这些铝的生物利用度的结果是中间先前报道的结果，从饮用水（F = 0.3%）和酸性SALP纳入饼干（F = 0.1%），使用相同的方法。考虑到食物与水中Al的口服生物利用度相似，以及它们对典型人类每日Al摄入量的贡献（分别为约95%和1.5%），这些结果表明食物对体循环的Al贡献更大，潜在的Al身体负担比饮用水更多。这些结果不支持的假设，即饮用水提供了不成比例的贡献，总铝从胃肠道吸收。
Oral aluminum (Al) bioavailability from drinking water has been previously estimated, but there is little information on Al bioavailability from foods. It was suggested that oral Al bioavailability from drinking water is much greater than from foods. The objective was to further test this hypothesis. Oral Al bioavailability was determined in the rat from basic [26Al]-sodium aluminum phosphate (basic SALP) in a process cheese. Consumption of ∼1g cheese containing 1.5% or 3% basic SALP resulted in oral Al bioavailability (F) of ∼0.1% and 0.3%, respectively, and time to maximum serum26Al concentration (Tmax) of 8–9h. These Al bioavailability results were intermediate to previously reported results from drinking water (F∼0.3%) and acidic-SALP incorporated into a biscuit (F∼0.1%), using the same methods. Considering the similar oral bioavailability of Al from food vs. water, and their contribution to the typical human’s daily Al intake (∼95% and 1.5%, respectively), these results suggest food contributes much more Al to systemic circulation, and potential Al body burden, than does drinking water. These results do not support the hypothesis that drinking water provides a disproportionate contribution to total Al absorbed from the gastrointestinal tract.