Effects of high-intensity interval training on adipose tissue lipolysis, inflammation, and metabolomics in aged rats
Effects of high-intensity interval training on adipose tissue lipolysis, inflammation, and metabolomics in aged rats
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DOI：
10.1007/s00424-020-02351-y
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发表时间：
2020-01
期刊：
影响因子：
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通讯作者：
Lei Sun;Fanghui Li;Tao Li;Zhu Min;Luo-Dan Yang;Hao-En Gao;Da-Shuai Wu;Tian Xie
中科院分区：
文献类型：
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作者：
Lei Sun;Fanghui Li;Tao Li;Zhu Min;Luo-Dan Yang;Hao-En Gao;Da-Shuai Wu;Tian Xie
高强度间歇训练（HIIT）是中等强度连续训练（MICT）的一种时间效率高的替代方案，可改善老年人的代谢健康。然而，这两种方法之间的脂肪组织代谢差异尚不清楚。在这里，我们评估了HIIT和MICT对老年大鼠代谢表型的影响。HIIT显著降低脂肪量，增加瘦体重百分比，降低脂肪与瘦体重比，降低血清高敏C-反应蛋白，增加血清白细胞介素-10水平，并降低肾周脂肪组织瘦素与大鼠相比，在久坐（SED）组。HIIT还增加了脂肪组织和血清中的双烯醇酮、皮质醇和皮质酮。与SED组相比，两种运动方式均增强了脂肪敏感性脂肪酶和脂肪甘油三酯脂肪酶的表达，并降低了棕榈酸、硬脂酸、十八碳二烯酸、尿素、1-十七烷醇和α-生育酚。MICT与甘油脂代谢相关，而HIIT与类固醇激素生物合成相关。总体而言，HIIT显示出比MICT更有利的抗炎活性调节。
High-intensity interval training (HIIT) is a time-efficient alternative to moderate-intensity continuous training (MICT) to improve metabolic health in older individuals. However, differences in adipose tissue metabolism between these two approaches are unclear. Here, we evaluated the effects of HIIT and MICT on metabolic phenotypes in aged rats. HIIT significantly decreased fat mass, increased percent lean mass, decreased fat-to-lean ratio, reduced serum high-sensitivity C-reactive protein, increased serum interleukin-10 levels, and decreased perirenal adipose tissue leptin compared with rats in the sedentary (SED) group. HIIT also increased pregnenolone, cortisol, and corticosterone in both adipose tissue and serum. Both exercise modalities enhanced hormone-sensitive lipase and adipose triglyceride lipase expression compared with the SED group and decreased palmitic acid, stearic acid, octadecadienoic acid, urea, 1-heptadecanol, and α-tocopherol. MICT was related to glycerolipid metabolism, whereas HIIT was related to steroid hormone biosynthesis. Overall, HIIT showed more favorable regulation of anti-inflammatory activity than MICT.