Peptide-mediated behaviors in marine organisms Evidence for a common theme
Peptide-mediated behaviors in marine organisms Evidence for a common theme
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海洋生物中肽介导的行为共同主题的证据
DOI：
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发表时间：
2005
影响因子：
2.3
通讯作者：
D. Rittschof
中科院分区：
文献类型：
--
作者：
D. Rittschof
生物学有许多共同的主题，如DNA，RNA，其他生物聚合物，以及它们的构建模块。化学通讯系统也有类似的共同主题。一个例子是氨基酸、糖和核苷酸作为食物线索的常见用法。通讯系统很可能是从预先存在的分子的特定意义的进化开始的。用于特定通讯的一类分子是肽。这些肽是作为水生环境中生物体气味的一部分产生的，可以在一定距离或通过接触起作用。证据是一种常见类型的肽受体系统。四肽介导的行为，三个在不同的甲壳类动物和一个在软体动物，进行了讨论。这些行为对生存具有重要意义，由丝氨酸蛋白酶产生的纳摩尔浓度的肽引起，并且需要碱性羧基末端氨基酸。这些行为包括对新壳的吸引、对活猎物的吸引、释放幼虫和诱导幼虫定居行为。对纯二肽和三肽的研究表明，相同的分子引起幼虫释放行为、壳吸引反应和幼虫定居行为。纯化合物在纳摩尔或更低浓度下有效。类似的肽在脊椎动物中作为响应创伤的特异性线索起作用。因此，使用丝氨酸蛋白酶产生的肽的肽通信似乎是一个共同的主题。
Biology has many common themes such as DNA, RNA, the other biopolymers, and their building blocks. Chemical communication systems have similar common themes. An example is the common usage of amino acids, sugars, and nucleotides as food cues. It is likely that communication systems began with the evolution of specific meanings for preexisting molecules. One class of molecules used in specific communication is peptides. These peptides are generated as part of the body odor of organisms in aquatic environments and can act at a distance or by contact. Evidence is given for a common type of peptide receptor system. Four peptide-mediated behaviors, three in diverse crustacean groups and one in a mollusc, are discussed. The behaviors are of major survival importance, are cued by nanomolar concentrations of peptides generated by serine proteases, and the basic carboxy terminal amino acid is required. The behaviors include attraction to new shells, attraction to living prey, release of larvae, and induction of larval settlement behavior. Studies with pure di- and tripeptides show the same molecules evoke larval release behavior, shell attraction responses, and larval settlement behavior. The pure compounds are effective at nanomolar or lower concentrations. Similar peptides function as specific cues in vertebrates in response to wounding. Thus, peptide communication using serine protease-generated peptides appears to be a common theme.
C3a 过敏毒素的活性位点：亲脂性和定向残基的贡献。
影响因子：
2.9
作者：
Unson,CG;Erickson,BW;Hugli,TE
通讯作者：
Hugli,TE