Spontaneous activation of RNA-sensing pathways in autoimmune disease.
Spontaneous activation of RNA-sensing pathways in autoimmune disease.
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DOI：
10.1016/j.coi.2013.09.011
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发表时间：
2013-12
影响因子：
7
通讯作者：
Bolland S
中科院分区：
文献类型：
--
作者：
Crampton SP;Bolland S
多种细胞内RNA传感先天免疫途径已与自身免疫性疾病有关。通过内吞途径摄取的RNA相关配体激活TLR，并主要影响免疫细胞。这种类型的激活被核酸特异性抗体增强并诱导炎症程序。相反，细胞质RNA传感途径的自发激活主要靶向非造血组织，并且它们对自身免疫性疾病的作用继发于循环中干扰素的释放。病理由先天途径的自发激活引起的事实意味着可能被感测为致病性的内源性RNA配体通常存在于免疫细胞和非免疫细胞中。
Multiple intracellular RNA sensing innate immune pathways have been linked to autoimmune disease. RNA-related ligands taken up by the endocytic pathway activate TLRs, and affect primarily immune cells. This type of activation is enhanced by nucleic acid-specific antibodies and induces an inflammatory program. In contrast, spontaneous activation of cytoplasmic RNA sensing pathways target mostly non-hematopoietic tissues and their effect on autoimmune disease is secondary to the release of interferon in the circulation. The fact that pathologies result from spontaneous activation of innate pathways implies that endogenous RNA ligands that might be sensed as pathogenic are commonly found in both immune and non-immune cells.
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